is a rapid-growing, multidrug-resistant, non-tuberculous mycobacterial species responsible for a variety of human infections, such as cutaneous and pulmonary infections. infections are very difficult to eradicate due to the natural and acquired multidrug resistance profiles of . Thus, there is an urgent need for the development of effective drugs or regimens against infections. Here, we report the activity of a US Food and Drug Administration approved drug, thiostrepton, against . We found that thiostrepton significantly inhibited the growth of wild-type strains, subspecies, clinical isolates, and drug-resistant mutants in vitro and in macrophages. In addition, treatment of macrophages with thiostrepton significantly decreased proinflammatory cytokine production in a dose-dependent manner, suggesting an inhibitory effect of thiostrepton on inflammation induced during infection. We further showed that thiostrepton exhibits antimicrobial effects in vivo using a zebrafish model of infection.
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| http://dx.doi.org/10.3390/molecules24244511 | DOI Listing |
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