Using first principles calculations, we investigated the possibility of selecting multiple toxic gases using one substrate material. Here, we explored the transport property of H, N, O, CO, CO, NO and NH gas molecules on two-dimensional graphitic carbon nitride (2D g-CN). The homonuclear molecule such as H, N, and O has very weak adsorption energy (equal to or less than 0.1 eV) and also CO has an adsorption energy of 0.23 eV. In the typical toxic gas molecule adsorption systems, we found an appreciable charge transfer. In CO and NH adsorption systems, the charge transfer of 0.397 and 0.418 electrons from the molecule to the substrate was found, while the NO molecule gained 0.124 electrons from the substrate. Due to this large amount of charge transfer, we obtained large adsorption energies of 4.57, 1.29, and 1.93 eV in CO, NO and NH systems. Moreover, through the I-V curve calculations, we found large difference in the current. The calculated current was 21, 13.11, and 16.16 μA for CO, NO and NH systems at the bias voltage of 0.5 V. Our results imply that the 2D g-CN can be a superior substrate material for sensing of multiple toxic gases.
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http://dx.doi.org/10.1088/1361-6528/ab61d2 | DOI Listing |
Curr Drug Saf
January 2025
Topiwala National Medical College & BYL Nair Charitable Hospital, Clinical Pharmacology, India.
Introduction: This case study presents a rare and fatal instance of Toxic Epidermal Necrolysis (TEN) and Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome in a 51-year-old male patient diagnosed with Rheumatoid Arthritis (RA).
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Heliyon
January 2025
Pharmaceutical Sciences and Technology Program, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, 10330, Thailand.
Hyaluronic acid (HA) is a popular surface modifier in targeted cancer delivery due to its receptor-binding abilities. However, HA alone faces limitations in lipid solubility, biocompatibility, and cell internalization, making it less effective as a standalone delivery system. This comprehensive study aimed to explore a dynamic landscape of complexation in HA-based nanoparticles in cancer therapy, examining diverse aspects from influential modifiers to emerging trends in cancer diagnostics.
View Article and Find Full Text PDFHeliyon
January 2025
Department of Pharmaceutical Chemistry, Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad, Pakistan, 44000.
Objective: The rise of drug-resistant bacteria, viruses, and fungi has prompted the search for new drugs without cross-resistance to current treatments. As a result, the aim of this research was to synthesize various types of dihydropyrimidinones heterocyclic compounds and screened them for their antibiotic properties.
Methodology: Newly synthesized dihydropyrimidinone derivatives were characterized spectroscopically using proton NMR (HNMR), and FT-IR.
Nanoscale
January 2025
Department of Biomedical Engineering, Faculty of Engineering and Natural Sciences, Istinye University, Istanbul 34396, Türkiye.
MXenes, a family of two-dimensional transition metal carbides and nitrides, exhibit exceptional properties such as high electrical conductivity, large surface area, and chemical versatility, making them ideal candidates for various dialysis applications. One prominent application of MXenes lies in the efficient removal of toxic metals and harmful dyes from wastewater. Their unique structure allows for rapid adsorption and selective separation, significantly improving purification processes.
View Article and Find Full Text PDFBackground: Hyperkalemia, generally defined as serum potassium levels greater than 5.0 mEq/L, poses significant clinical risks, including cardiac toxicity and muscle weakness. Its prevalence and severity increase in patients with chronic kidney disease (CKD), diabetes mellitus, and heart failure (HF), particularly when compounded by medications like Angiotensin converting inhibitors, Angiotensin receptor blockers, and potassium sparing diuretics.
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