AI Article Synopsis
- Parkinson's disease (PD) is a neurodegenerative disorder marked by the loss of dopamine-producing neurons and buildup of α-synuclein in the brain, linked to neuroinflammation.
- Research showed that Bacopa monnieri (BM) can reduce inflammation in PD by lowering pro-inflammatory cytokines, α-synuclein levels, and reactive oxygen species in an animal model.
- Pre-treatment with BM proved more effective than co- or post-treatment, indicating its potential as a novel therapeutic option for various central nervous system disorders.
Article Abstract
Parkinson's disease (PD) is a common neurodegenerative disorder characterized by loss of dopaminergic neurons in substantia nigra region and the presence of α-synuclein aggregates in the striatum and surrounding areas of brain. Evidences suggest that neuroinflammation plays a role in the progression of PD. We examined the neuro-protective effects of Bacopa monnieri (BM) in regulating neuroinflammation. Administration of BM suppressed the level of pro-inflammatory cytokines, decreased the levels of α-synuclein, and reduced reactive oxygen species (ROS) generation in PD animal model. Pre-treatment of BM showed more prominent results as compare to co- and post-treatment. Results suggest that Bacopa can limit inflammation in the different areas of brain, thus, offers a promising source of novel therapeutics for the treatment of many CNS disorders.
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| http://dx.doi.org/10.1007/s11011-019-00526-w | DOI Listing |
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