Adenoma detection rate (ADR) is a quality marker of colonoscopy and operator performance. Prior studies evaluating the effect of an extended workday on the ADR reported variable outcomes that remain controversial. Given the variable results of prior studies and the potential legal implications of reduced ADR in the afternoon, we aimed to further evaluate this parameter and its effect on ADR. We performed a systematic review of the PubMed, CINAHL and Scopus electronic databases. Studies were included if they reported ADR in patients undergoing colonoscopy in the morning session and the afternoon session. Afternoon sessions included both sessions following a morning shift and half-day block shifts. Subgroup analyses were performed for ADR comparing morning and afternoon colonoscopies in a continuous workday, advanced ADRs (AADRs) and polyp detection rates (PDRs) were also compared. Thirteen articles with 17 341 (61.2%) performed in the morning session and 10 994 (38.8%) performed in the afternoon session were included in this study. There was no statistical significance in the ADR or AADR between morning and afternoon sessions, respectively [relative risk (RR) 1.06, 95% confidence interval (CI) 0.99-1.14] and (RR 1.19, 95% CI 0.95-1.5). Afternoon procedures had a significantly higher PDR than morning procedures (RR 0.93, 95% CI 0.88-0.98). ADR was not significantly influenced in the afternoon session when operators continued to perform procedures throughout the day or on a half-day block schedule.
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http://dx.doi.org/10.1097/MEG.0000000000001596 | DOI Listing |
Gut Microbiome (Camb)
November 2024
Yakult Europe BV, Science Department, Almere, The Netherlands.
The latest Yakult Science Study Day was held virtually on 2 November 2023. Aimed at healthcare professionals, researchers, and students, a variety of experts explored the latest gut microbiome research and what it means in practice. The morning sessions discussed the role of the microbiome in health and disease, the rapid advancements in DNA sequencing and implications for personalised nutrition, the current state of evidence on health benefits associated with fermented foods, prebiotics and probiotics and the challenges involved in interpreting research in this area.
View Article and Find Full Text PDFMol Pharm
December 2024
Office of Pharmaceutical Quality, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland 20993-0002, United States.
This report summarizes the proceedings for Day 3 of the workshop titled "". This day focused on the current and future drug product quality applications of PBBM from the innovator and generic industries as well as the regulatory agencies perspectives. The presentations, which included several case studies, covered the applications of PBBM in generic drug product development, applications of virtual bioequivalence trials to support formulation bridging and the utility of absorption modeling in clinical pharmacology assessments.
View Article and Find Full Text PDFCurr Biol
November 2024
Department of Psychology, University of Chicago, Chicago, IL 60637, USA.
Previous research shows that a single session of anodal transcranial direct current stimulation (tDCS) to the left dorsolateral prefrontal cortex (dlPFC) can improve the accuracy of episodic memory retrieval, but stimulation effects are not always found and may be moderated by time of day. Here, we report the results from a rigorous clinical trial (NCT03723850) designed to replicate these tDCS findings in younger adults and extend them to cognitively normal older adults. We conducted the largest double-blind, between-subjects tDCS study on memory retrieval in younger and older adults to date.
View Article and Find Full Text PDFFront Nutr
November 2024
Movement, Sport, Health and Sciences Laboratory (M2S), UFR APS, University of Rennes 2-ENS Cachan, Rennes, France.
Cureus
October 2024
Anaesthesiology and Perioperative Medicine, Singapore General Hospital, Singapore, SGP.
Background The probability of postoperative nausea and vomiting (PONV) may be influenced by the time of day. Since there has been no recent study published exploring this association, we conducted a study to determine the effect of surgical time of day on PONV. Methods With ethics approval, data of all patients undergoing elective non-cardiac non-neurosurgery, with a high risk of PONV, and which had a 24-hour assessment of PONV between October 2017 and December 2020 were extracted.
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