A PHP Error was encountered

Severity: Warning

Message: file_get_contents(https://...@gmail.com&api_key=61f08fa0b96a73de8c900d749fcb997acc09): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests

Filename: helpers/my_audit_helper.php

Line Number: 143

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 143
Function: file_get_contents

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 209
Function: simplexml_load_file_from_url

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 994
Function: getPubMedXML

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3134
Function: GetPubMedArticleOutput_2016

File: /var/www/html/application/controllers/Detail.php
Line: 574
Function: pubMedSearch_Global

File: /var/www/html/application/controllers/Detail.php
Line: 488
Function: pubMedGetRelatedKeyword

File: /var/www/html/index.php
Line: 316
Function: require_once

Relevance of Sex and Subtype in Patients With IBS: An Exploratory Study of Gene Expression. | LitMetric

Relevance of Sex and Subtype in Patients With IBS: An Exploratory Study of Gene Expression.

Biol Res Nurs

Digestive Disorders Unit, Division of Intramural Research, National Institute of Nursing Research, National Institutes of Health, Bethesda, MD, USA.

Published: January 2020

AI Article Synopsis

  • A study was conducted to investigate the relationship between psychological factors, stress, and gastrointestinal function in patients with irritable bowel syndrome (IBS) compared to healthy controls.
  • * Researchers evaluated gene expression in blood samples from 27 IBS participants and 43 healthy controls, finding significant differences in stress levels and specific gene expressions.
  • * The results suggest that metabolism, inflammation, and stress-related processes are connected to IBS, emphasizing the importance of considering sex and IBS subtypes in future analyses.

Article Abstract

Background: Psychological state, stress level, and gastrointestinal function are intricately related and relevant to symptom exacerbation in patients with irritable bowel syndrome (IBS), but genetic contributors to this brain-gut connection are not fully understood. The purpose of this exploratory study was to compare gene expression in participants with IBS to that of healthy controls (HC) and to examine patterns of expression in participants with IBS by sex and IBS subtype.

Method: Participants were recruited to an ongoing protocol at the National Institutes of Health. Differences in demographic and clinical characteristics were assessed using descriptive statistics and Mann-Whitney tests. Expression levels of 84 genes were evaluated in peripheral whole blood using Custom RT Profiler polymerase chain reaction (PCR) Arrays, and data analysis was performed through GeneGlobe Data Analysis Center.

Results: Participants with IBS ( = 27) reported greater levels of perceived stress ( = .037) and differed in expression values of ±2 for the genes , , , , , and compared to HC ( = 43). Further analyses by sex and IBS subtype revealed differential patterns of gene expression related to the endocannabinoid system, cytokines, stress, and sex steroid hormones.

Conclusions: Diverse yet interconnected processes such as metabolism, inflammation, immunity, social behavior, and pain are associated with differences in gene expression between participants with IBS and HC. These findings lend support for genomic associations with the brain-gut connection in patients with IBS and highlight the relevance of sex and IBS subtype in performing such analyses.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7068753PMC
http://dx.doi.org/10.1177/1099800419889189DOI Listing

Publication Analysis

Top Keywords

gene expression
16
participants ibs
16
expression participants
12
sex ibs
12
ibs
10
relevance sex
8
patients ibs
8
exploratory study
8
brain-gut connection
8
data analysis
8

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!