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High- versus Low-dose Oxytocin Regimens for Labor Augmentation: A Systematic Review and Meta-analysis.
Am J Obstet Gynecol MFM
January 2025
Department of Obstetrics and Gynecology, Christiana Care Health System, Newark, DE; Delaware Center for Maternal Fetal Medicine, Newark, DE.
Objective: To assess whether high- versus low-dose oxytocin regimens for labor augmentation are associated with differential risk for low Apgar score, neonatal acidosis, and other adverse labor outcomes.
Data Sources: We searched electronic databases (MEDLINE, EMBASE, the Cochrane Library, CINAHL, Scopus, ClinicalTrials.gov) from inception up to March 2024 using combinations of the following keywords: "oxytocin," "oxytocin regimen," "oxytocin protocol," "oxytocin dosage," "active management," "high dose protocol," "low dose protocol," "augmentation of labor.
The Effect of Preinduction Cervical Ripening With Synthetic Hygroscopic Dilators on Maternal Outcomes of Women With Previous Caesarean Pregnancy: A Single-Group Clinical Trial.
J Pregnancy
December 2024
Department of Preventive and Social Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India.
Preinduction cervical ripening in previous caesarean pregnancy is limited to intracervical Foley catheter. This study is aimed at finding the vaginal birth rates, improvement of Bishop score, and safety of osmotic dilator (Dilapan-S) among women with previous caesarean pregnancy. We conducted this single-group clinical study after the approval of the institute ethics committee, clinical trial registration, and obtaining informed consent.
View Article and Find Full Text PDFComparison of balloon catheter and oral misoprostol for cervical ripening in women with pre-labor rupture of membranes: A Finnish randomized controlled trial.
Acta Obstet Gynecol Scand
December 2024
Department of Obstetrics and Gynecology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Introduction: Pre-labor rupture of membranes (PROM) occurs in about 8% of term pregnancies with over 70% delivering spontaneously within 24 h. However, prolonged PROM increases the risk of chorioamnionitis and neonatal sepsis. While misoprostol and oxytocin are considered safe and effective methods of labor induction, most guidelines do not encourage balloon catheter (BC) use following PROM given concerns about increased risk of chorioamnionitis.
View Article and Find Full Text PDFIs Oxytocin Induction at Labor a Risk Factor for Developmental Hip Dysplasia?
J Clin Med
September 2024
Department of Pediatrics, Lokman Hekim University Hospital, 06510 Ankara, Turkey.
Article Synopsis
- - Developmental hip dysplasia (DHD) is a common condition with unclear causes, and this study investigates whether synthetic oxytocin used during childbirth may be a risk factor for DHD.
- - The research compared healthy girls born via vaginal delivery, focusing on those who received low-dose oxytocin induction versus those who did not, analyzing hip examination results and ultrasounds performed at various intervals.
- - Findings indicated that low-dose oxytocin induction does not increase the risk of DHD, while also suggesting the need for further research on oxytocin's effects and its receptors.
Oxytocin regimen used for induction of labor and pregnancy outcomes.
Am J Obstet Gynecol MFM
December 2024
Northwestern University, Chicago, IL (Mallett and Grobman).
Article Synopsis
- A recent study analyzed the effect of oxytocin dosage on cesarean delivery rates and adverse outcomes in low-risk nulliparous patients undergoing labor induction at 39 weeks or more.
- The research compared mid- to high-dose oxytocin regimens with low-dose regimens, finding that higher doses were associated with fewer cesarean deliveries, without increasing negative perinatal outcomes.
- The study was a secondary analysis of a larger randomized trial and utilized various statistical methods to evaluate the impact of the different oxytocin dosages on the primary outcomes.
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