On a general theoretical foundation for endocrinology.

Sci Prog

Mathematics Institute, University of Warwick, Coventry, UK.

Published: March 2019

Hormones are messenger molecules that distribute across all tissues and thus operate on the whole-organism level. Moreover, a given hormone typically affects a number of different biological processes. As such, hormones coordinate concerted cooperation between the cells and tissues of an organism, a phenomenon that has been termed 'organismal harmony'. Furthermore, a concept that has recently been gaining traction is that hormones mediate or represent life history trade-offs, which are ultimately moulded by evolutionary pressures. Here, this concept is extended to include all 'decisions' or 'choices' that are made at the organismal level. A formal framework is sketched to explore the proposition that organismal biology, together with the 'fitness landscape', suffices in principle to determine minimalistic dynamics of the endocrine system.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10424553PMC
http://dx.doi.org/10.1177/0036850419825926DOI Listing

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