There is no universally agreed definition of well-being as a subjective experience, but Huppert and So (2013) adopted and systematically applied the definition of well-being as positive mental health-the opposite of the common mental disorders described in standard mental health classifications (e.g., ). We extended their theoretical approach to include multi-item scales, using 2 waves of nationally representative U.S. adult samples to develop, test, and validate our multidimensional measure of well-being (WB-Pro). This resulted in a good-fitting a priori (48-item, 15-factor) model that was invariant over time, education, gender, and age; showed good reliability (coefficient αs .81-.93), test-retest correlation (.73-.85; M = .80), and convergent/discriminant validity based on a multitrait-multimethod analysis, and relations with demographic variables, selected psychological measures, and other multidimensional and purportedly unidimensional well-being measures. Further, we found that items from 2 widely used, purportedly unidimensional well-being measures loaded on different WB-Pro factors consistent with a priori predictions based on the WB-Pro factor structure, thereby calling into question their claimed unidimensionality and theoretical rationale. Because some applications require a short global measure, we used a machine-learning algorithm to construct 2 global well-being short versions (five- and 15-item forms) and tested these formative measures in relation to the full-form and validity criteria (to download short and long versions see https://ippe.acu.edu.au/research/research-instruments/wb-pro). The WB-Pro appears to be one of the most comprehensive measures of subjective well-being, based on a sound conceptual model and empirical support, with broad applicability for research and practice, as well as providing a framework for evaluating the breadth of other well-being measures. (PsycINFO Database Record (c) 2020 APA, all rights reserved).
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Biomed Pharmacother
December 2024
Center of Excellence on Natural Products for Neuroprotection and Anti-Ageing, Chulalongkorn University, Bangkok 10330, Thailand; Research, Innovation and International Affairs, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, Thailand. Electronic address:
Model organisms are commonly used to study human diseases; we set out to understand the relevance of several model organisms with relation to the σ1R protein. The study explored the interactions of σ1R with various agonists, antagonists across different species. Ligand and protein-protein (σ1R-BiP) docking approaches were used to understand the significance of σ1R in modulating neuroprotective mechanisms and its potential role in Alzheimer's.
View Article and Find Full Text PDFCortex
December 2024
Department of Speech, Language and Hearing Sciences, University of Texas at Austin, United States; Department of Neurology, Dell Medical School, University of Texas at Austin, United States.
Script training is a speech-language intervention designed to promote fluent connected speech via repeated rehearsal of functional content. This type of treatment has proven beneficial for individuals with aphasia and apraxia of speech caused by stroke and, more recently, for individuals with primary progressive aphasia (PPA). In the largest study to-date evaluating the efficacy of script training in individuals with nonfluent/agrammatic primary progressive aphasia (nfvPPA; Henry et al.
View Article and Find Full Text PDFJ Acquir Immune Defic Syndr
December 2024
Division of Nephrology, Albert Einstein College of Medicine, Montefiore Health System, Bronx, NY.
Background: The Veterans Aging Cohort Study (VACS) Index is a summary measure of routinely obtained clinical variables that predicts numerous health outcomes. Since there are currently no tools to predict acute kidney injury (AKI) in persons with HIV (PWH), we investigated the association of preadmission VACS Index with hospital AKI in PWH.
Methods: We conducted an observational study of PWH hospitalized in a New York City health system between 2010-2019.
Med Phys
December 2024
Department of Physics, Lakehead University, Thunder Bay, Ontario, Canada.
Background: This study investigates a multi-angle acquisition method aimed at improving image quality in organ-targeted PET detectors with planar detector heads. Organ-targeted PET technologies have emerged to address limitations of conventional whole-body PET/CT systems, such as restricted axial field-of-view (AFOV), limited spatial resolution, and high radiation exposure associated with PET procedures. The AFOV in organ-targeted PET can be adjusted to the organ of interest, minimizing unwanted signals from other parts of the body, thus improving signal collection efficiency and reducing the dose of administered radiotracer.
View Article and Find Full Text PDFClin J Sport Med
October 2024
Sports Medicine and Orthopaedics, Children's Health Andrews Institute, Plano, Texas.
Objective: To examine differences in the presentation and management of concussion in younger children (aged 4-8 years) versus preadolescents (9-12 years) and identify factors that influence recovery time.
Design: Retrospective analysis of prospectively collected data.
Setting: Pediatric sports medicine and orthopedics clinic.
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