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Non-adrenergic vasopressors for vasodilatory shock or perioperative vasoplegia: a meta-analysis of randomized controlled trials.
Crit Care
December 2024
Australian and New Zealand Intensive Care Research Centre (ANZIC-RC), School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
Background: Excessive exposure to adrenergic vasopressors may be harmful. Non-adrenergic vasopressors may spare adrenergic agents and potentially improve outcomes. We aimed to conduct a systematic review and meta-analysis of randomized controlled trials (RCTs) to evaluate the efficacy of non-adrenergic vasopressors in adult patients receiving vasopressor therapy for vasodilatory shock or perioperative vasoplegia.
View Article and Find Full Text PDF[Intoxication due to apricot pits].
Ned Tijdschr Geneeskd
October 2024
Maastricht UMC+, Maastricht. Afd. Interne Geneeskunde.
Background: Apricot seeds are recommended online for their alleged cancer-fighting and energy-boosting properties. However, they contain high levels of cyanogenic glycosides. Ingesting just a few apricot pits (1-3) can result in severe symptoms and fatalities have been reported after consuming more than 20 pits.
View Article and Find Full Text PDFHydroxocobalamin Versus Methylene Blue for Treatment of Vasoplegic Shock Following Cardiopulmonary Bypass: A Systematic Review and Meta-analysis.
J Cardiothorac Vasc Anesth
December 2024
Anaesthetics Department, Royal Sussex County Hospital, University Hospitals Sussex, United Kingdom.
Article Synopsis
- * A systematic review and meta-analysis of 263 patients revealed no significant difference in vasopressor requirements, but hydroxocobalamin improved mean arterial pressure and reduced total vasopressor doses at 1 and 6 hours.
- * The results suggest hydroxocobalamin is more effective than methylene blue for improving hemodynamics, but more high-quality research is needed to confirm these findings.
Improved biochemical and neurodevelopmental profiles with high-dose hydroxocobalamin therapy in cobalamin C defect.
J Inherit Metab Dis
January 2025
Division of Metabolic Diseases and Hepatology, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Article Synopsis
- Cobalamin C (Cbl-C) defect leads to serious health issues like methylmalonic acidemia and cognitive impairment, but treatment with hydroxocobalamin (OH-Cbl) doses remains uncertain.
- * A study compared high-dose OH-Cbl treatment in newborn screening (NBS)-diagnosed patients to low-dose treatment in other groups, showing that the high-dose group had significantly better metabolic and neurodevelopmental outcomes.
- * Results indicated that while high-dose treatment improved overall health markers and cognitive performance, it did not affect the incidence of maculopathy, signaling a need for clearer dosing guidelines in Cbl-C treatment.*
Vitamin B12 Deficiency-Induced Neuropathy and Cognitive and Motor Impairment in the Elderly: A Case Study.
Food Nutr Bull
June 2024
B12 Institute, Rotterdam, the Netherlands.
Vitamin B12 deficiency can present with a variety of neurological and cognitive symptoms. Especially in elderly patients, vitamin B12 deficiency can be easily overlooked because symptoms may be attributed to comorbid conditions or solely to the aging process. In this case study, we present two patients, a 71-year-old man and a 74-year-old female, with vitamin B12 deficiency.
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