The original version of this article unfortunately contained a mistake. In the third paragraph of "Discussion," two references were missing.
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HLA molecular mismatches and induced donor-specific tolerance in combined living donor kidney and hematopoietic stem cell transplantation.
Front Immunol
April 2024
The Comprehensive Transplant Center (CTC) at Northwestern University Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.
Introduction: We investigated the potential role of HLA molecular mismatches (MM) in achieving stable chimerism, allowing for donor-specific tolerance in patients undergoing combined living donor kidney and hematopoietic stem cell transplantation (HSCT).
Methods: All patients with available DNA samples (N=32) who participated in a phase 2 clinical trial (NCT00498160) where they received an HLA mismatched co-transplantation of living donor kidney and facilitating cell-enriched HSCT were included in this study. High-resolution HLA genotyping data were used to calculate HLA amino acid mismatches (AAMM), Eplet MM, three-dimensional electrostatic mismatch scores (EMS-3D), PIRCHE scores, HLA-DPB1 T-cell epitope group MM, HLA-B leader sequence MM, and KIR ligands MM between the donor and recipient in both directions.
Background And Objectives: This study describes the use of the Epvix platform for virtual cross-matching (VC) of human leucocyte antigen (HLA)-compatible platelets for patients with immune platelet refractoriness, and demonstrates effectiveness of the selected platelets.
Materials And Methods: A prospective cohort of haematological patients was evaluated from 2018 to 2022. HLA-typed donor bank profile was previously uploaded to the Epvix platform.
[Discussion on two common problems in renal transplantation donor-specificity discrimination of anti-human leukocyte antigen antibody].
Zhonghua Yi Xue Za Zhi
May 2023
Department of Organ Transplantation, Changhai Hospital Affiliated to Naval Medical University, Shanghai 200433, China.
Antibody-mediated rejection (AMR) is a key factor affecting the long-term survival of renal allografts. Donor-specific antibody (DSA) is the etiology of AMR. So it is very important to accurately detect DSA.
View Article and Find Full Text PDFCorrigendum: Molecular HLA mismatching for prediction of primary humoral alloimmunity and graft function deterioration in paediatric kidney transplantation.
Front Immunol
March 2023
Department of Surgery, University of Cambridge, Cambridge, United Kingdom.
Article Synopsis
- The article discusses the correction of previous findings related to a specific DOI, ensuring accuracy in scientific reporting.
- It emphasizes the importance of updating published research to reflect new insights or rectify errors.
- The corrected article aims to maintain integrity and trust in the scientific community by providing reliable information.
Estimation of Antibody-Verified Eplet Mismatch Load, 2-Field HLA Resolution vs Imputation in a Large Cohort of European Donors.
Transplant Proc
November 2022
Immunology Department, Marqués de Valdecilla University Hospital, Santander, Spain; Autoimmunity and Transplantation Research Group, Research Institute "Marqués de Valdecilla" (IDIVAL), Santander, Spain. Electronic address:
Background: The assessment of class II eplet mismatch load is useful to determine the risk of chronic rejection in solid organ transplantation. However, high-resolution (2-field) HLA typing is mandatory to accurately define eplet mismatches. The imputation of the most frequent allele has been used in retrospective studies.
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