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| http://dx.doi.org/10.1136/bcr-2019-233619 | DOI Listing |
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Intradural extramedullary tuberculoma in a case of disseminated tuberculosis: A case report.
Surg Neurol Int
December 2024
Department of Orthopedics, KEM Hospital and Seth GS Medical College, Mumbai, Maharashtra, India.
Background: Intradural extramedullary tuberculoma of the spinal cord (IETSC) is an exceedingly rare manifestation of tuberculosis (TB) affecting the central nervous system.
Case Description: A 33-year-old immunocompetent female with disseminated TB, including pulmonary involvement and leptomeningeal tuberculomas, developed progressive paraplegia and urinary incontinence over 2 months. Magnetic resonance imaging revealed diffuse intradural extramedullary soft tissue from C7 to L2 vertebral levels, indicative of abscess formation and severe spinal cord compression.
Deep Learning for Discrimination of Early Spinal Tuberculosis from Acute Osteoporotic Vertebral Fracture on CT.
Infect Drug Resist
January 2025
Department of Orthopedics, First Affiliated Hospital, Chongqing Medical University, Chongqing, People's Republic of China.
Background: Early differentiation between spinal tuberculosis (STB) and acute osteoporotic vertebral compression fracture (OVCF) is crucial for determining the appropriate clinical management and treatment pathway, thereby significantly impacting patient outcomes.
Objective: To evaluate the efficacy of deep learning (DL) models using reconstructed sagittal CT images in the differentiation of early STB from acute OVCF, with the aim of enhancing diagnostic precision, reducing reliance on MRI and biopsies, and minimizing the risks of misdiagnosis.
Methods: Data were collected from 373 patients, with 302 patients recruited from a university-affiliated hospital serving as the training and internal validation sets, and an additional 71 patients from another university-affiliated hospital serving as the external validation set.
Craniovertebral Junction Tuberculosis, a Rare Presentation With Hypoglossal and Facial Nerve Palsy: A Case Report.
JBJS Case Connect
October 2024
Department of Orthopaedics, All India Institute of Medical Sciences, Rishikesh, India.
Case: A 47-year-old man presented with neck pain, restricted neck movements, along with involvement of facial and hypoglossal nerve. On the basis of clinico-radiological correlation, the patient was diagnosed with craniovertebral junction tuberculosis and was started on antitubercular therapy (ATT). Failing the conservative trial, the patient was operated and occipitocervical fusion was done with bone grafting.
View Article and Find Full Text PDFDifferences analysis between spinal tuberculosis and brucella spondylitis with preoperative non-invasive differential diagnosis.
Eur Spine J
January 2025
Department of Orthopaedics, Lanzhou University Second Hospital, Lanzhou, Gansu, 730000, China.
Objective: Spinal tuberculosis (STB) and Brucella spondylitis (BS) represent two types of granulomatous infections affecting the spine, which exhibit significant similarities that often result in misdiagnosis and overlooked diagnoses during preoperative evaluations. This study aims to identify non-invasive evaluative indicators that facilitate the differentiation between STB and BS.
Methods: This study conducted a retrospective collection of clinical features, laboratory tests, and imaging characteristics from 89 patients diagnosed with STB and 66 patients diagnosed with BS.
Comparison of the Effects of H37Rv and Infiltration on Tumor Necrosis Factor-Alpha and Interleukin-1 Beta Expression in Osteoblasts.
Surg Infect (Larchmt)
January 2025
First Clinical Medical College, Ningxia Medical University, Yinchuan, China.
This study aims to compare the expression levels of tumor necrosis factor-alpha (TNF-α) and interleukin-1 beta (IL-1β) in osteoblasts infiltrated with H37Rv (H37Rv) and to understand the differential bone destruction in spinal tuberculosis (STB) versus spondylitis (BS). Primary osteoblasts were isolated and cultured from the cranial bones of 2-5 days old mice and characterized by alkaline phosphatase (ALP) staining and alizarin red staining (ARS). H37Rv and were cultured to the logarithmic phase, and transfection solutions were prepared.
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