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Toxicokinetic profiling of VRP-034: Evaluating its potential in mitigating polymyxin-B-associated nephrotoxicity.
Int J Antimicrob Agents
November 2024
Venus Medicine Research Centre, Bhatoli Kalan, Baddi, India. Electronic address:
This study assessed the nephrotoxicity and toxicokinetic profile of VRP-034 [a novel formulation of polymyxin B (PMB)] compared with marketed PMB over a 7-day repeat-dose regimen. Three objectives were pursued: evaluating PMB pharmacokinetics in both groups, alongside assessing the impact of VRP-034 on mitigating PMB-associated kidney injury; analysing the reversibility of kidney injury; and validating novel kidney injury biomarkers against traditional markers using histopathological scoring. Sixty-eight Sprague-Dawley rats were divided into three groups: 30 in each of the marketed PMB and VRP-034 groups, and eight in the control group.
View Article and Find Full Text PDFAmelioration of full-thickness cutaneous wound healing using stem cell exosome and zinc oxide nanoparticles in rats.
Heliyon
November 2024
Department of Surgery, Anesthesiology, and Radiology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, 35516, Egypt.
Background: Wound healing is a complex procedure that requires the coordination of several factors, so this study aimed to assess the zinc oxide nanoparticles' regenerated effect and stem cell exosomes on full-thickness wounds in rats.
Methods: Seventy-two Wistar male rats were subjected to a full-thickness skin defect (20 mm2) on the dorsal surface of each rat between two shoulder joints. The rats were randomized into four groups (18/group) according to wound treatments.
A brief history of the cortical thick ascending limb: a systems-biology perspective.
Am J Physiol Renal Physiol
January 2025
Epithelial Systems Biology Laboratory, Systems Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States.
Article Synopsis
- The cortical thick ascending limb (CTAL) of the kidney was first characterized by Maurice Burg in 1973, revealing its role in actively reabsorbing NaCl while having low water permeability, allowing it to produce dilute urine during high water intake.
- In the 1980s, Greger and Schlatter identified the specific membrane transport processes for NaCl, which were further characterized at the molecular level by various researchers in the 1990s using cDNA cloning and advancements in genome sequencing.
- By the 2010s, mathematical models were developed to explore CTAL transport mechanisms, leading to investigations into Burg's 'static head' phenomenon, the adaptation of short CTALs in juxtamedullary nephrons,
Renal tubular damage as an independent risk factor for all-cause and cardiovascular mortality in a community-based population: the Takahata study.
Clin Exp Nephrol
November 2024
Department of Public Health and Hygiene, Yamagata University Graduate School of Medical Science, 2-2-2, Iida-Nishi, Yamagata, 990-9585, Japan.
Background: Renal tubular damage plays a crucial role in the development of end-stage kidney disease, a risk factor for cardiovascular events and mortality. However, the relationship between renal tubular damage and all-cause and cardiovascular mortality rates in the general population remains unclear. To address this gap, we conducted a cohort study in the general population using the urinary β2-microglobulin-creatinine ratio (UBCR) as a marker of renal tubular damage.
View Article and Find Full Text PDFAmeliorative effect of rutecarpine supplementation against cisplatin-induced nephrotoxicity in rats via inhibition of monocyte chemoattractant protein-1, intercellular adhesion molecule-1, high-mobility group box 1, and nuclear factor kappa B.
Biotechnol Appl Biochem
November 2024
Department of Emergency, Banan Hospital Affiliated to Chongqing Medical University, Chongqing, China.
Cisplatin, the pioneering heavy metal compound, stands out as a potent drug for the treatment of various solid tumors. However, its clinical utility is hampered by notable toxicity and adverse effects, particularly nephrotoxicity. The potency of rutecarpine, a phytochemical, in mitigating cisplatin-induced nephrotoxicity was assessed in the present study.
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