AI Article Synopsis
- In the developing Drosophila central nervous system, neural progenitor selection involves lateral inhibition mechanisms regulated by Notch signaling and other proneural genes.
- Recent findings indicate that additional proneural genes, specifically SoxNeuro and worniu, play a role in this process, highlighting a previously unknown connection with epithelial-mesenchymal transition (EMT) genes.
- The study reveals an expanded network of genes that are crucial for neural progenitor selection, suggesting that this regulatory framework may be conserved across various biological systems.
Article Abstract
In the developing Drosophila central nervous system (CNS), neural progenitor (neuroblast [NB]) selection is gated by lateral inhibition, controlled by Notch signaling and proneural genes. However, proneural mutants still generate many NBs, indicating the existence of additional proneural genes. Moreover, recent studies reveal involvement of key epithelial-mesenchymal transition (EMT) genes in NB selection, but the regulatory interplay between Notch signaling and the EMT machinery is unclear. We find that SoxNeuro (SoxB family) and worniu (Snail family) are integrated with the Notch pathway, and constitute the missing proneural genes. Notch signaling, the proneural, SoxNeuro, and worniu genes regulate key EMT genes to orchestrate the NB selection process. Hence, we uncover an expanded lateral inhibition network for NB selection and demonstrate its link to key players in the EMT machinery. The evolutionary conservation of the genes involved suggests that the Notch-SoxB-Snail-EMT network may control neural progenitor selection in many other systems.
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| http://dx.doi.org/10.1016/j.celrep.2019.11.038 | DOI Listing |
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