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| http://dx.doi.org/10.4103/1673-5374.270302 | DOI Listing |
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Exosome crosstalk between cancer stem cells and tumor microenvironment: cancer progression and therapeutic strategies.
Stem Cell Res Ther
November 2024
Department of General Surgery, The Fourth Affiliated Hospital, China Medical University, Shenyang, 110032, China.
Cancer stem cells (CSCs) represent a small yet pivotal subset of tumor cells endowed with self-renewal capabilities. These cells are intricately linked to tumor progression and are central to drug resistance, metastasis, and recurrence. The tumor microenvironment (TME) encompasses the cancer cells and their surrounding milieu, including immune and inflammatory cells, cancer-associated fibroblasts, adjacent stromal tissues, tumor vasculature, and a variety of cytokines and chemokines.
View Article and Find Full Text PDFDexmedetomidine regulates exosomal miR-29b-3p from macrophages and alleviates septic myocardial injury by promoting autophagy in cardiomyocytes via targeting glycogen synthase kinase 3β.
Burns Trauma
November 2024
Department of Burn, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin Er Road, Shanghai 200025, China.
Article Synopsis
- The study investigated how dexmedetomidine (Dex) enhances autophagy in heart cells during sepsis by examining the role of exosomes and microRNAs.
- Researchers collected plasma exosomes from rats with sepsis to analyze their effects on cardiomyocytes, focusing on the expression of miR-29b-3p, which was found to be higher in Dex-treated exosomes.
- The results indicated that Dex not only promotes autophagy in heart cells but also helps protect against cell death by influencing miR-29b-3p levels in exosomes, suggesting potential therapeutic targets for sepsis-related heart injury.
Endothelial-derived exosomes: A novel therapeutic strategy for LPS-induced myocardial damage with anisodamine.
Int J Biol Macromol
December 2024
State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China. Electronic address:
Sepsis-induced myocardial dysfunction presents significant challenges in clinical management and is associated with increased mortality. Anisodamine (654-1/-2) has potentials in alleviating cardiac and endothelial impairments associated with sepsis. Exosomes, small vesicles secreted by cells, carry various bioactive molecules, such as nucleic acids, proteins, and lipids.
View Article and Find Full Text PDFExosomes Induce Crosstalk Between Multiple Types of Cells and Cardiac Fibroblasts: Therapeutic Potential for Remodeling After Myocardial Infarction.
Int J Nanomedicine
October 2024
Key Laboratory of Medical Electrophysiology of the Ministry of Education, Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, Sichuan, People's Republic of China.
Recanalization therapy can significantly improve the prognosis of patients with acute myocardial infarction (AMI). However, infarction or reperfusion-induced cardiomyocyte death, immune cell infiltration, fibroblast proliferation, and scarring formation lead to cardiac remodeling and gradually progress to heart failure or arrhythmia, resulting in a high mortality rate. Due to the inability of cardiomyocytes to regenerate, the healing of infarcted myocardium mainly relies on the formation of scars.
View Article and Find Full Text PDFAberrant NSUN2-mediated m5C modification of exosomal LncRNA MALAT1 induced RANKL-mediated bone destruction in multiple myeloma.
Commun Biol
October 2024
Department of Oncology and Hematology, The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, 250001, China.
The impact of exosome-mediated crosstalk between multiple myeloma (MM) cells and osteoclasts (OCs) on bone lesions remains to be investigated. Here, we identified NSUN2 and YBX1-mediated m5C modifications upregulated LncRNA MALAT1 expression in MM cells, which could be transported to OCs via exosomes and promote bone lesions. Methodologically, RNA-seq was carried out to detect the cargoes of exosomes.
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