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Assessment of Long-Term Engagement in Aerobic Versus Resistance Exercise on 20-Year Cardiovascular Disease Incidence (2002-2024): The ATTICA Epidemiological Cohort Study.
J Clin Med
January 2025
Department of Nutrition and Dietetics, School of Health Sciences and Education, Harokopio University, 176 76 Athens, Greece.
: The aim of this study was to assess whether aerobic exercise, as opposed to resistance training or a combination of both, is associated with long-term cardiovascular outcomes. : The ATTICA study is a population-based cohort study with a 20-year follow-up (2002-2022); it was conducted in the Attica region, Greece, and included 3042 adult participants (45 ± 11 years, 1518 females). Physical activity engagement in aerobic, resistance, or combined exercise, and 20-year tracking, together with information regarding atherosclerotic cardiovascular disease (ASCVD) incidence were available for 1988 participants (45 ± 12 years old, 987 males, 1001 females).
View Article and Find Full Text PDFCracking the Code of Calcification: How Presence and Burden among Intracranial Arteries Influence Stroke Incidence and Recurrence.
AJNR Am J Neuroradiol
January 2025
University of Padova (M.C.); University of Bologna (M.O.A.); Department of Radiology (R.C, R.S., L.S.), Azienda Ospedaliero Universitaria (A.O.U.) di Cagliari, Cagliari, Sardegna, Italy; Department of Neurology and Stroke Program (S.C.), University of Maryland School of Medicine, Baltimore, Maryland, United States; CVPath Institute (R.V.), Gaithersburg, Maryland, United States; Department of Radiology (G.DR.), Azienda San Camillo Forlanini, Rome, Lazio, Italy; Department of Epidemiology (D.B.), Erasmus Medical Center, Rotterdam, South Holland, Netherlands; Department of Radiology and Nuclear Medicine (D.B.), Erasmus Medical Center, Rotterdam, South Holland, Netherlands; Mayo Clinic (L.S.), Rochester, Minnesota, United States.
Background: Intracranial atherosclerosis accounts for about 8% of all strokes in Western societies but the influence of arterial calcification on plaque instability is a topic on ongoing debate.
Purpose: Explore the association between the presence and burden of calcium in atherosclerotic plaques among intracranial arteries with the risk of clinical or silent stroke events through a systematic review and meta-analysis.
Data Sources: Adhering to PRISMA guidelines, studies from PubMed and Embase were analyzed up to May 2024.
Cadmium promotes hyaluronan synthesis by inducing hyaluronan synthase 3 expression in cultured vascular endothelial cells via the c-Jun N-terminal kinase-c-Jun pathway.
Toxicology
January 2025
Department of Environmental Health, Faculty of Pharmaceutical Sciences, Toho University, 2-1-1 Miyama, Funabashi, Chiba 274-8510, Japan. Electronic address:
Cadmium is a heavy metal risk factor for various cardiovascular diseases, such as atherosclerosis. In atherosclerotic lesions, hyaluronan, a glycosaminoglycan consisting of β4-glucuronic acid-β3-N-acetylglucosamine disaccharides repeats, is highly accumulated, regulating signal transduction, cell migration, and angiogenesis. Hyaluronan is synthesized by hyaluronan synthase (HAS)1-3 in the plasma membrane and secreted into the extracellular space.
View Article and Find Full Text PDFCarotid artery atherosclerotic stenosis is an important annual cause of stroke in the United States. Moreover, the incidence of carotid artery stenosis is significantly increasing due to the widespread popularity of high fat and high salt diets, sedentary lifestyles, and the increasing age of the population. Of major importance to cardiovascular specialists is the fact that individuals with atherosclerotic carotid artery stenosis can have a prevalence of atherosclerotic coronary artery disease as high as 50 to 75%.
View Article and Find Full Text PDFIschemia with Non-Obstructive Coronary Arteries (INOCA) in the 2024 European Society of Cardiology (ESC) Guidelines for the management of chronic coronary syndromes.
Eur Heart J Acute Cardiovasc Care
January 2025
Cardiovascular Clinical Research Center, Leon H. Charney Division of Cardiology, Department of Medicine, NYU Grossman School of Medicine, New York, NY, USA.
Background: Chronic coronary syndromes (CCS) occur commonly in the absence of flow-limiting epicardial coronary stenoses. Ischemia or angina with no obstructive coronary arteries (INOCA/ANOCA) may be caused by coronary microvascular disease, coronary artery spasm, myocardial bridging, diffuse atherosclerosis, or a combination of disorders.
Methods & Results: We highlight the new recommendations in the 2024 European Society of Cardiology (ESC) guidelines on CCS relevant to the diagnosis and management of INOCA/ANOCA.
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