AI Article Synopsis
- Serum procalcitonin (PCT) and C-reactive protein (CRP) are important biomarkers for identifying infections in patients with hematologic disorders, particularly when discerning between bacterial and non-bacterial causes of fever.
- Analysis of data from 614 febrile episodes in 511 patients revealed that PCT levels were significantly elevated in cases of Gram-negative bacterial infections compared to fungal infections, while both PCT and CRP were higher in bacterial infections than in non-bacterial episodes.
- The study identified that in non-neutropenic patients, both biomarkers effectively distinguished bacteremia from non-bacteremia, whereas in neutropenic cases, only PCT was reliable for diagnosis, indicating variability in diagnostic accuracy based on neutrophil status
Article Abstract
Background: Serum procalcitonin (PCT) and C-reactive protein (CRP) are biomarkers of infection. In patients with hematologic disorders with or without hematopoietic stem cell transplantation (HSCT), it is difficult to distinguish bloodstream infections from aseptic causes of febrile episodes. The objective of this study was to investigate diagnostic values of PCT and CRP in predicting systemic bacterial infection in patients with hematologic malignancies.
Methods: Clinical and laboratory data of 614 febrile episode cases from 511 patients were analyzed. Febrile episodes were classified into four groups: (1) culture-positive bacterial infection by Gram-positive cocci (GPC), (2) culture-positive bacterial infection by Gram-negative bacilli (GNB), (3) fungal infection, and (4) viral infection or a noninfectious etiology.
Results: Of 614 febrile cases, systemic bacterial infections were confirmed in 99 (16.1%) febrile episodes, including 38 (6.2%) GPC and 61 (9.9%) GNB infections. PCT levels were significantly higher in GNB infectious episodes than those in febrile episodes caused by fungal infection (0.58 ng/mL (95% CI: 0.26-1.61) vs. 0.22 ng/mL (0.16-0.38), P = 0.047). Bacterial infectious episodes showed higher PCT and CRP levels than non-bacterial events (PCT: 0.49 (0.26-0.93) ng/mL vs. 0.20 (0.18-0.22) ng/mL, P < 0.001; CRP: 76.6 (50.5-92.8) mg/L vs. 58.0 (51.1-66.5) mg/L, P = 0.036). For non-neutropenic febrile episodes, both PCT and CRP discriminated bacteremia from non-bacteremia. However, in neutropenic febrile episodes, PCT only distinguished bacteremia from non-bacteremia. In non-neutropenic episode, both PCT and CRP showed good diagnostic accuracy (AUC: 0.757 vs. 0.763). In febrile neutropenia, only PCT discriminated bacteremia from non-bacterial infection (AUC: 0.624) whereas CRP could not detect bacteremia (AUC: 0.500, 95% CI: 0.439-0.561, P > 0.05).
Conclusions: In this single-center observational study, PCT was more valuable than CRP for discriminating between bacteremia and non-bacteremia independent of neutropenia or HSCT.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6903763 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0225765 | PLOS |
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