Seven previously unknown sesquiterpenoids and norsesquiterpenoids, rhodocoranes F-L (-), were isolated from the fermentation broth of the basidiomycete . Their structures were elucidated utilizing 1D and 2D NMR techniques as well as HRESIMS; they are unusual noracorane, spiro[4.4]nonene, and acorane-type sesquiterpenoids. They include the first naturally occurring cyclopentylidenefuranones (-) and the new tricyclic scaffold of . Metabolites - exhibited a general mild antimycotic activity, while - also displayed cytotoxic effects.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1021/acs.jnatprod.9b00871 | DOI Listing |
Life (Basel)
December 2024
Facultad de Ciencias de la Tierra, Universidad Estatal Amazónica (UEA), Vía Tena km 2½, Puyo 160150, Pastaza, Ecuador.
Essential oils are investigated due to their biological activity, and the Amazon rainforest, with its rich biodiversity, is a promising source of therapeutic compounds. The aim of this study was to evaluate the essential oil from the leaves of as an antifungal agent, thus contributing to the search for alternatives that can address the growing resistance to conventional antifungals. leaves were collected in the Ecuadorian Amazon and their essential oil was obtained by steam distillation.
View Article and Find Full Text PDF<i>Ormocarpum trichocarpum</i> (Taub.) Engl. is a shrub or small tree harvested from the wild as a source of food, traditional medicines and wood.
View Article and Find Full Text PDFTranspl Int
December 2024
Service de Parasitologie-Mycologie, 3IHP, Inserm U1071, M2iSH, USC-INRAE 1382, Université Clermont Auvergne, CHU Clermont-Ferrand, Clermont-Ferrand, France.
Unlabelled: Intestinal microsporidiosis caused by is an opportunistic infection that especially affects solid organ transplant (SOT) recipients. Management revolves around tapering the immunosuppressive regimen and/or using a specific anti-microsporidia treatment, but only fumagillin has demonstrated efficacy for treatment of this infection. Since fumagillin has been commercially discontinued, nitazoxanide is increasingly being used in this indication.
View Article and Find Full Text PDFAm J Transl Res
November 2024
Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional Ciudad de México, México.
The L. genus, belonging to the Moraceae family, includes around 850 species that are widely distributed in tropical and subtropical regions around the world; including the Eastern Mediterranean, Asia, Africa, Australia, and a large territory of America. Among the most important species are , , , , , Vahl, , , , and .
View Article and Find Full Text PDFPestic Biochem Physiol
January 2025
Jiangsu Key Laboratory for the Research and Utilization of Plant Resources, Jiangsu Province Engineering Research Center of Eco-cultivation and High-value Utilization of Chinese Medicinal Materials, Institute of Botany, Jiangsu Province and Chinese Academy of Sciences (Nanjing Botanical Garden Mem. Sun Yat-Sen), Nanjing 210014, China. Electronic address:
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!