An efficient base promoted nitrile-alkyne domino-type cyclization for multicomponent assembly of imidazoles from alkynes, nitriles, and tBuOK has been developed, which could run even in the absence of solvent on a gram scale with complete atom economy. This method contributes directly to reaching the synthesis of valuable imidazole derivatives from readily available raw materials.
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Base-Promoted Nitrile-Alkyne Domino-Type Cyclization: A General Method to Trisubstituted Imidazoles.
Org Lett
December 2019
State Key Laboratory of Applied Organic Chemistry , Lanzhou University, Lanzhou 730000 , P.R. China.
An efficient base promoted nitrile-alkyne domino-type cyclization for multicomponent assembly of imidazoles from alkynes, nitriles, and tBuOK has been developed, which could run even in the absence of solvent on a gram scale with complete atom economy. This method contributes directly to reaching the synthesis of valuable imidazole derivatives from readily available raw materials.
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