AI Article Synopsis
- The study aimed to analyze the relationship between certain trace elements and hypothyroidism, addressing conflicting previous findings.
- The meta-analysis included 32 observational studies, revealing that patients with hypothyroidism had significantly lower levels of selenium and zinc, but higher levels of lead compared to healthy individuals.
- The research highlights the need for more high-quality studies with larger samples to better understand the connections between trace elements and hypothyroidism.
Article Abstract
The relationship between thyroid hormones metabolism and trace element levels has biological plausibility; however, previous reports that compared trace element levels in patients with hypothyroidism and healthy individuals yielded conflicting results. Therefore, the aim of this meta-analysis was to investigate the association between selected trace elements (i.e., selenium (Se), zinc (Zn), iron (Fe), manganese (Mn), copper (Cu), lead (Pb)), and magnesium (Mg) concentrations in patients with hypothyroidism and healthy controls. Electronic databases, including PubMed, Scopus, Embase, and Science Direct, were searched systematically until September 2019. Thirty-two observational studies were included in the final analyses. Hedges' g tests were used to estimate effect sizes, as trace element concentrations were reported using different measurement units across the studies. Selenium (Hedges' g = - 0.52; 95% CI = [- 1.05, - 0.002]; P = 0.049) and Zn (Hedges' g = - 0.86; 95% CI = [- 1.66, - 0.06]; P = 0.035) concentrations were significantly lower, whereas Pb concentrations were significantly higher (Hedges' g = 0.34; 95% CI = [0.10, 0.59]; P = 0.006) in patients with hypothyroidism compared with healthy controls. There were no differences in the concentrations of Fe, Cu, Mn, and Mg between the groups. Patients with hypothyroidism exhibited lower Se and Zn and increased Pb concentrations compared with healthy controls. High-quality studies with larger sample sizes are required to explicate the link between trace element status and hypothyroidism.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s12011-019-01963-5 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Structural determinants of oxygen resistance and Zn-mediated stability of the [FeFe]-hydrogenase from .
Proc Natl Acad Sci U S A
January 2025
Laboratory for Protein Crystallography, Institute for Protein Research, Osaka University, Suita, Osaka 565-0871, Japan.
[FeFe]-hydrogenases catalyze the reversible two-electron reduction of two protons to molecular hydrogen. Although these enzymes are among the most efficient H-converting biocatalysts in nature, their catalytic cofactor (termed H-cluster) is irreversibly destroyed upon contact with dioxygen. The [FeFe]-hydrogenase CbA5H from has a unique mechanism to protect the H-cluster from oxygen-induced degradation.
View Article and Find Full Text PDFIron deficiency and fatigue in inflammatory bowel disease: A systematic review.
PLoS One
January 2025
Department of Gastroenterology, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom.
Background: It is unclear what impact iron deficiency has on fatigue in people with inflammatory bowel disease (IBD). This systematic review examined the evidence of whether iron deficiency, with or without anaemia, was associated with fatigue in IBD. Fatigue is a common symptom in patients with IBD that can be difficult to manage and treat.
View Article and Find Full Text PDFInteractions between contaminants and the trophic ecology of two seabirds in a coastal lagoon of the Gulf of California.
Ecotoxicology
January 2025
Unidad Académica Mazatlán, Instituto de Ciencias del Mar y Limnología, Universidad Nacional Autónoma de México, Mazatlán, Sinaloa, México.
Monitoring the dynamics of contaminants in ecosystems helps understand their potential effects. Seabirds have been used as biomonitors of marine ecosystems for this purpose. However, exposure and vulnerability to pollutants are understudied in tropical species, and the relationships between various pollutants and the trophic ecology of seabirds are poorly understood.
View Article and Find Full Text PDFAssociations of Exposure to 56 Serum Trace Elements with the Prevalence and Severity of Acute Myocardial Infarction: Omics, Mixture, and Mediation Analysis.
Biol Trace Elem Res
January 2025
Department of Geriatrics, The Second Affiliated Hospital, Nanjing Medical University, Nanjing, 210011, China.
Several studies have reported associations between specific heavy metals and essential trace elements and acute myocardial infarction (AMI). However, there is limited understanding of the relationships between trace elements and AMI in real-life co-exposure scenarios, where multiple elements may interact simultaneously. This cross-sectional study measured serum levels of 56 trace elements using inductively coupled plasma mass spectrometry.
View Article and Find Full Text PDFCoffee is a popular beverage with significant commercial and social importance. The study aimed to determine the fatty acids profile, volatile compounds, and concentration of major and trace elements (Na, Mg, K, Ca, P, S, Fe, Mn, Cu, Zn, Cr, Ni, Cd, and Pb) in the two most important varieties of coffee, namely arabica and robusta. The leaching percentages of mineral elements and the effect of boiling time on the transfer of elements to aqueous extracts were also determined.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!