Peri-implantitis, a disease caused by bacteria, affects dental implants in patients. It is widely treated with antibiotics, however, with growing antibiotic resistance new strategies are required. Titanium-copper alloys are prospective antibacterial biomaterials, with the potential to be a remedy against peri-implantitis and antibiotic resistance. The aim of this study was to investigate Ti-Cu alloys, exploring how Cu content (up to 10 wt%) and ageing affect the material properties. Electron microscopy, X-ray diffraction, hardness testing, bacteriological culture, and electrochemical testing were employed to characterize the materials. It was found that alloys with above 3 wt% Cu had two phases and ageing increased the volume fraction of TiCu. An un-aged alloy of 5 wt% Cu showed what could be TiCu, in addition to the α-Ti phase. The hardness gradually increased with increased Cu additions, while ageing only affected the alloy with 10 wt% Cu (due to changes in microstructure). Ageing resulted in faster passivation of the alloys. After two hours the aged 10 wt% Cu alloy was the only material with an antibacterial effect, while after six hours, bacteria killing occurred in all alloys with above 5 wt% Cu. In conclusion, it was possible to tune the material and antibacterial properties of Ti-Cu alloys by changing the Cu concentration and ageing, which makes further optimization towards an antibacterial material promising.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6926654 | PMC |
| http://dx.doi.org/10.3390/ma12234017 | DOI Listing |
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Article Synopsis
- Titanium implants are commonly used in orthopedics and dental fields but face challenges like infection and poor bone integration, which can lead to complications after surgery.
- The study investigates a titanium-copper alloy implant coated with nanosilver/poly (lactic-co-glycolic acid) (NSPTICU) to enhance antibacterial properties and promote bone integration.
- Results show that NSPTICU improves cell differentiation and exhibits strong antibacterial effects, aiding in bone healing and reducing inflammation in animal models.
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