AI Article Synopsis
- Cell mechanotransduction is a growing research field focusing on how cells react to changes in their environment, especially the extracellular matrix.
- New materials, including elastic and viscoelastic substances, are being developed for studying cell interactions, moving from 2D models to more complex 3D environments.
- The article discusses key concepts like the molecular clutch model and the role of various extracellular matrix proteins in mechanotransduction, highlighting their influence on gene regulation by factors like YAP/TAZ.
Article Abstract
Cell mechanotransduction is an area of intense research focus. Until now, very limited tools have existed to study how cells respond to changes in the extracellular matrix beyond, for example, mechanical deformation studies and twisting cytometry. However, emerging are a range of elastic, viscoelastic and even purely viscous materials that deform and dissipate on cellular length and timescales. This article reviews developments in these materials, typically translating from 2D model surfaces to 3D microenvironments and explores how cells interact with them. Specifically, it focuses on emerging concepts such as the molecular clutch model, how different extracellular matrix proteins engage the clutch under viscoelastic-stress relaxation conditions, and how mechanotransduction can drive transcriptional control through regulators such as YAP/TAZ.
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| http://dx.doi.org/10.1002/adhm.201901259 | DOI Listing |
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