Antimalarial Activity and Toxicological Assessment of Extract against Infections in Mice.

Evid Based Complement Alternat Med

School of Medicine, Walailak University, Nakhon Si Thammarat 80160, Thailand.

Published: November 2019

The resistance of malaria parasites to the current antimalarial drugs has led to the search for novel effective drugs. has been traditionally used for the treatment of malaria, but the scientific evidence to substantiate this claim is still lacking. Therefore, the present study aimed at evaluating the antimalarial activity and toxicity of an aqueous stem extract of in a mouse model. The antimalarial activity of an aqueous stem extract of was determined by a 4-day suppressive test in mice infected with chloroquine-sensitive ANKA. The extract was administered orally at different doses of 200, 400, and 600 mg/kg body weight. The levels of parasitaemia, survival time, body weight change, and food and water consumption of the mice were determined. The acute toxicity of the extract was assessed in the mice for 14 days after the administration of a single oral dose of 5000 mg/kg. An aqueous stem extract of exhibited a significant dose-dependent reduction of parasitaemia in -infected mice at all dose levels compared to the reduction in the negative control. Extract doses of 200, 400, and 600 mg/kg body weight suppressed the levels of parasitaemia by 46.90, 58.39, and 71.26%, respectively. The extract also significantly prolonged the survival times of the -infected mice compared to the survival times of the negative control mice. In addition, at all dose levels, the extract prevented body weight loss in -infected mice. For the acute toxicity, there were no significant alterations in the biochemical parameters and in the histopathology. In conclusion, the aqueous stem extract of possesses antimalarial properties. A single oral dose of 5000 mg/kg body weight had no significant toxic effects on the function and structure of the kidneys and liver. These results support its use in traditional medicine for the treatment of malaria.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6877991PMC
http://dx.doi.org/10.1155/2019/2324679DOI Listing

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