Purpose: The aim of this study was to define the role of dystrophin Dp71 in corneal angiogenesis.
Methods: Inflammation-induced corneal neovascularization experiments were performed in -null mice and C57BL/6J wild-type mice.
Results: The corneal neovascular area covered by neovascularization was larger in the injured corneas of the -null mice compared to the corneas of the wild-type mice: 40.72% versus 26.33%, respectively (p<0.005). Moreover, increased angiogenesis was associated with a high expression of vascular endothelial growth factor (VEGF). Similarly, aortic ring assays showed a significant enhancement of the neovascular area.
Conclusions: These results suggest that dystrophin Dp71 could play an important role as a negative regulator of corneal angiogenesis.
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Article Synopsis
- Duchenne and Becker muscular dystrophies (DMD, BMD) are neuromuscular disorders linked to cognitive and behavioral issues, with studies suggesting that the severity of these issues may be connected to the loss of different dystrophin proteins.
- This study focused on Dp71-null mice, which lack the shortest dystrophin isoform, revealing abnormal social behaviors, vocalization, and changes in anxiety levels, but no impact on myopathy or learning/memory related to fear.
- The findings suggest that mutations affecting Dp71 might contribute to social and emotional problems commonly seen in DMD, supporting the idea that losing multiple dystrophin isoforms can exacerbate behavioral issues.
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