Matricaria chamomella is of medicinal importance and has been used for its various pharmacological activities against different diseases due to the presence of polyphenolic compounds especially flavonoids and their glycosides. Flowers of the chamomile plant were studied for the quantification of total polyphenolic compounds and flavonoids aglycon. Total polyphenolic compounds obtained were 83.22mg as gallic acid equivalents/g of plant material; while for the determination of flavonoids aglycon the plant material was subjected to acid hydrolysis before quantification through HPLC-PDA. Results showed that luteolin, quercetin, apigenin, isorhamnetin and kaempferol were quantified. Apigenin was found in highest concentration (0.071mg/ml) while amounts of the rest of the flavonoids quantified are: luteolin (0.012mg/ml), quercetin (0.032mg/ml), kaempferol (0.001mg/ml) and isorhamnetin (0.023 mg/ml).
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J Nat Med
January 2025
Chongqing Academy of Chinese Materia Medica, Chongqing University of Chinese Medicine, Chongqing, 402760, China.
Non-Hodgkin lymphomas (NHL), including diffuse large B-cell lymphoma (DLBCL), Burkitt lymphoma (BL), and follicular lymphoma (FL), predominantly arise from B cells undergoing germinal center (GC) reactions. The transcriptional repressor B-cell lymphoma 6 (BCL6) is indispensable for GC formation and contributes to lymphomagenesis via its BTB domain-mediated suppression of target genes. Dysregulation of BCL6 underpins the pathogenesis of GC-derived NHL.
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December 2024
Chemical Technology Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur (Himachal Pradesh), 176061, India; Academy of Scientific and Innovative Research, (AcSIR), Ghaziabad, 201002, India. Electronic address:
The aim of current work was to develop a novel, simple, sensitive, and reliable method for screening and quantification of thirty-two polyphenol compounds from Cordia myxa (C. myxa) using Ultra Performance Liquid Chromatography Photodiode Array detector (UPLC-PDA). With the help of the quaternary solvent manager and a comparison study of seven different columns packed with silica particles that are less than two micron thick (1.
View Article and Find Full Text PDFChem Biodivers
January 2025
Universidade Federal de Pernambuco, Pharmaceutical Sciences, Rua Prof Arthur de Sá, SN, 50740521, Recife, BRAZIL.
This study aimed to provide a comprehensive understanding of the acute and subacute safety and phytochemical profile of pomegranate leaves, aligning with the growing interest in sustainable, plant-based therapeutics. The phytochemical composition, the acute and subacute toxicity of a spray-dried hydroethanolic extract from pomegranate leaves (SDE) were investigated using experimental animal models. Utilizing UV-visible spectrophotometry and liquid chromatography-mass spectrometry (LC-MS), a diverse array of tannins and flavonoids, totaling 38 compounds, was identified.
View Article and Find Full Text PDFDiscov Oncol
January 2025
Hunan Provincial Hospital of Integrated Traditional Chinese and Western Medicine, No. 58, Yuelu District, Changsha, 410006, Hunan, China.
Objective: Rosmarinic acid (RosA) is a natural polyphenol compound that has been shown to be effective in the treatment of inflammatory disease and a variety of malignant tumors. However, its specific mechanism for the treatment of lung adenocarcinoma (LUAD) has not been fully elucidated. Therefore, this study aims to clarify the mechanism of RosA in the treatment of LUAD by integrating bioinformatics, network pharmacology and in vivo experiments, and to explore the potential of the active ingredients of traditional Chinese medicine in treating LUAD.
View Article and Find Full Text PDFJ Agric Food Chem
January 2025
Laboratory of Bioactives (LABBIO), Food and Nutrition Graduate Program (PPGAN), Federal University of the State of Rio de Janeiro (UNIRIO), Rio de Janeiro 22290-240, Brazil.
Phenolic compounds (PC) were analyzed by UHPLC-ESI-QTOF-MS in two sorghum genotypes, harvested in two growing seasons (GS) at five distinct days after flowering (DAF) to evaluate how genotype/GS influences the PC synthesis and antioxidant capacity during grain growth. Total phenolic contents were strongly correlated with antioxidant capacity ( > 0.9, < 0.
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