AI Article Synopsis

Article Abstract

Many types of cancer are initially susceptible to chemotherapy, but during treatment, patients may develop resistance to therapy. Knowing that acquisition of drug resistance is a major clinical problem in antineoplastic treatment, the present work aimed to present, through a literature review, the development of chemoresistant cells lines as a model in experimental oncology. A total of 110 drug-resistant cell lines, mainly from lung tumors and leukemias, have been developed. In addition, it has been observed that the drugs used for induction of resistance represented the drugs used for first-line treatment of each neoplasia, since the ideal chemotherapeutic treatment to induce resistance in vitro aims at a better modulation of the therapeutic response in order to better study the mechanisms of resistance.

Download full-text PDF

Source
http://dx.doi.org/10.21873/anticanres.13858DOI Listing

Publication Analysis

Top Keywords

drug-resistant cell
8
cell lines
8
lines model
8
model experimental
8
experimental oncology
8
resistance
5
establishment drug-resistant
4
oncology review
4
review types
4
types cancer
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!