A simple and efficient method for the synthesis of isoquinolone and isocoumarin derivatives is reported. The method for the first time provides a one-step divergent synthesis of important isoquinolone and isocoumarin skeletons from benzoic acid by switching the coupling partners. In addition, a reliable mechanism has been proposed on the basis of experimental investigations, including kinetic isotope effect experiments, C labeling experiments, time-tracking experiments, and competitive experiments, as well as DFT calculation studies.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.orglett.9b03638 | DOI Listing |
Publication Analysis
Top Keywords
synthesis isoquinolone
12
isoquinolone isocoumarin
12
divergent synthesis
8
isocoumarin derivatives
8
benzoic acid
8
derivatives annulation
4
annulation benzoic
4
acid -vinyl
4
-vinyl amide
4
amide simple
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!