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| http://dx.doi.org/10.1111/hae.13901 | DOI Listing |
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Nationwide survey on HER2 and PD-L1 testing practices in gastric cancer across Japan.
Gastric Cancer
December 2024
Japanese Gastric Cancer Association, Kyoto, Japan.
Background: Since HER2 and PD-L1 testing are key to selecting drugs for first-line treatments in advanced gastric cancer, evaluating differences in these tests among institutions is necessary to standardize treatment.
Methods: A questionnaire survey was conducted targeting institutions certified by the Japanese Gastric Cancer Association.
Results: Responses were obtained from 155 institutions.
Acid-base parameters in venous blood - agreement between values from safePICO syringes and lithium-heparin vacutainer tubes.
Scand J Clin Lab Invest
December 2024
Department of Clinical Biochemistry, Gødstrup Hospital, Herning, Denmark.
Venous blood is considered an acceptable alternative to arterial blood for assessment of metabolic acid-base disorders. Also, venous sampling using lithium-heparin (Li-Hep) tubes is advantageous to arterial sampling using PICO syringes, the risk of complications being lower. Usage of partly filled tubes without firm knowledge about the clinical consequences is, however, a pre-analytic consideration.
View Article and Find Full Text PDFOptimized biomarker evaluation and molecular testing in the era of breast cancer precision medicine.
Biotech Histochem
October 2024
Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York, USA.
Ground breaking advances in medicine, driven in part by major technologic developments in molecular biology have led us to a new model for cancer care that has been termed personalized, or precision medicine. Precision medicine is a model for making medical decisions that employs an innovative clinical approach and advanced tumor testing methods that are tailored to understanding an individual patient's tumor biology and the molecular drivers of their disease. This medical model includes a combination of diagnostic testing and specific treatment options that can be offered to patients at presentation and in theory throughout the course of their disease as new mutations arise with the development of disease recurrence.
View Article and Find Full Text PDFPre-analytical stability and physiological fluctuations affect plasma steroid hormone outcomes: A real-world study.
J Steroid Biochem Mol Biol
November 2024
Department of Laboratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100730, China; State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100730, China. Electronic address:
Since steroids are crucial for diagnosing endocrine disorders, the lack of research on factors that affect hormone levels makes interpreting the results difficult. Our study aims to assess the stability of the pre-analytical procedure and the impact of hormonal physiological fluctuations using real-world data. The datasets were created using 12,418 records from individuals whose steroid hormone measurements were taken in our laboratory between September 2019 and March 2024.
View Article and Find Full Text PDFQuality considerations and major pitfalls for high throughput DNA-based newborn screening for severe combined immunodeficiency and spinal muscular atrophy.
PLoS One
June 2024
Department of Operative/Restorative Dentistry, Periodontology and Pedodontics, Ludwig-Maximilians-Universität München, Munich, Germany.
Background: Many newborn screening programs worldwide have introduced screening for diseases using DNA extracted from dried blood spots (DBS). In Germany, DNA-based assays are currently used to screen for severe combined immunodeficiency (SCID), spinal muscular atrophy (SMA), and sickle cell disease (SCD).
Methods: This study analysed the impact of pre-analytic DNA carry-over in sample preparation on the outcome of DNA-based newborn screening for SCID and SMA and compared the efficacy of rapid extraction versus automated protocols.
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