A species-specific ascaroside-type glycolipid was identified in the nematode using HPLC-ESI-(-)-MS/MS precursor ion scanning, HR-MS/MS, and NMR techniques. Its structure containing an l-3,6-dideoxy--hexose unit was established by total synthesis. The identification of this novel 4--ascaroside (caenorhabdoside) in along with the previous identification of 2--ascarosides (paratosides) in indicate that nematodes can generate highly specific signaling molecules by epimerization of the ascarylose building block downstream of the canonical β-oxidation cycle.
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Epimerization of an Ascaroside-Type Glycolipid Downstream of the Canonical β-Oxidation Cycle in the Nematode .
Org Lett
December 2019
Laboratory for Bioanalytical Chemistry, Institute of Chemistry , University of Neuchâtel, Avenue de Bellevaux 51 , CH-2000 Neuchâtel , Switzerland.
A species-specific ascaroside-type glycolipid was identified in the nematode using HPLC-ESI-(-)-MS/MS precursor ion scanning, HR-MS/MS, and NMR techniques. Its structure containing an l-3,6-dideoxy--hexose unit was established by total synthesis. The identification of this novel 4--ascaroside (caenorhabdoside) in along with the previous identification of 2--ascarosides (paratosides) in indicate that nematodes can generate highly specific signaling molecules by epimerization of the ascarylose building block downstream of the canonical β-oxidation cycle.
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