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Optimization and analytical validation of the Allplex HPV28 genotyping assay for use in first-void urine samples.
J Clin Microbiol
December 2024
International Agency for Research on Cancer, Lyon, France.
Despite first-void urine (FVU) being increasingly recognized as a credible specimen for human papillomavirus (HPV) detection, there is a lack of well-validated testing methods providing full quantitative genotyping required for vaccine impact monitoring from FVU samples. The Allplex HPV28 assay, capable of individually detecting 28 HPV genotypes, presents a promising method. We aimed to evaluate its genotype-specific performance on FVU samples, following optimization of FVU preanalytics.
View Article and Find Full Text PDFMultielectrode Radiofrequency Balloon Catheter for Paroxysmal Atrial Fibrillation: Results From the Global, Multicenter, STELLAR Study.
J Cardiovasc Electrophysiol
December 2024
Mercy General Hospital and Dignity Health Heart and Vascular Institute, Sacramento, California, USA.
Introduction: The safety and efficacy of paroxysmal atrial fibrillation (PAF) ablation with the HELIOSTAR multielectrode radiofrequency (RF) balloon catheter have been demonstrated in European studies; data from elsewhere are lacking. This prospective, multicenter study conducted in the United States, Italy, and China investigated the safety and efficacy of pulmonary vein isolation (PVI) using HELIOSTAR in drug-refractory symptomatic PAF.
Methods: The primary effectiveness endpoint (PEE) was 12-month freedom from documented atrial fibrillation/atrial flutter/atrial tachycardia plus freedom from acute procedural failure, nonstudy catheter failure, repeat ablation failure, direct current cardioversion (DCCV), and Class I/III antiarrhythmic drug (AAD) failure.
Gluten-free Diet, a Friend or a Foe, an American Perspective.
Plant Foods Hum Nutr
December 2024
Department of Plant and Environmental Sciences, Clemson University Pee Dee Research and Education Center, Florence, SC, 29506, USA.
Gluten proteins in cereal grains are often considered unsafe for health. Indeed, the dissemination of misinformation through various sources has led to a widespread misconception that the consumption of gluten by healthy individuals results in adverse health consequences and contributes to obesity. In recent years, many health-conscious consumers have started reducing or avoiding gluten consumption without a medical recommendation.
View Article and Find Full Text PDFComplementary Food Supplements Fill Energy and Protein Gaps among Children with Dietary Inadequacy in a Complementary Feeding Trial in Rural Bangladesh.
J Nutr
December 2024
Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.
Background: Few studies have evaluated the dietary impact of complementary food supplements (CFSs) designed to deliver macro- and micronutrients to children at risk for undernutrition. In a randomized controlled trial in rural Bangladesh, we previously reported that CFSs increased children's micronutrient adequacy.
Objectives: To longitudinally characterize energy and macronutrient intakes and inadequacies and evaluate the extent to which CFSs fill intake gaps.
Can Thinning Foster Forest Genetic Adaptation to Drought? A Demo-Genetic Modelling Approach With Disturbance Regimes.
Evol Appl
December 2024
INRAE, UR 629 Ecologie des Forêts Méditerranéennes (URFM), Domaine Saint Paul-Site Agroparc Avignon France.
Article Synopsis
- The study examines how management practices in forests can affect natural selection and adaptations to environmental stress, specifically drought.
- By using a modeling approach with the Luberon2 simulation, researchers explored the effects of tree thinning on growth traits and drought sensitivity over three generations.
- Results indicate that while thinning reduced competition pressures, traditional practices that favor larger trees may unintentionally enhance genetic traits that are not beneficial for long-term drought resilience.
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