AI Article Synopsis
- Incidence rates of breast cancer are rising among young women (≤40 years) in India, with environmental exposure to organochlorine (OC) compounds being a possible risk factor not yet thoroughly investigated.
- A case-control study compared 42 breast cancer patients aged ≤40 years with 42 matched controls to evaluate the levels of various OC compounds in their blood, including DDT and its metabolites.
- Results showed that young women with breast cancer had significantly higher levels of most OC compounds, indicating that exposure to these pesticides could be a significant modifiable risk factor for breast cancer in this age group.
Article Abstract
Background: Incidence rates of breast cancer are showing an increasing trend in young women (≤40 years) in India. Risk for breast cancer in this age group can be attributed only partially to various known risk factors. Environmental exposure to organochlorine (OC) compounds has been identified as a potential risk factor. However, the possible role of OC compounds in increasing breast cancer risk in young women has not been explored. This case-control study was planned with the objectives to assess the serum levels of OC compound in a North Indian population of young women.
Materials And Methods: Forty-two patients of breast cancer ≤ 40 years age and 42 age-matched controls were evaluated for exposure to OC compounds by performing assays in blood samples for pesticides such as dichlorodiphenyltrichloroethane (DDT) and its metabolites DDD and DDE; dieldrin; aldrin; methoxychlor, heptachlor; α-endosulfan; β-endosulfan; and hexachlorocyclohexane and its isomers (α, β, and γ).
Results: Young women with breast cancer were found to have significantly higher serum levels of all the OC compounds except aldrin, p, p' DDT, and methoxychlor.
Conclusions: Exposure to OC pesticides could be an important modifiable risk factor for breast cancer, especially in younger women.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6852623 | PMC |
| http://dx.doi.org/10.4103/sajc.sajc_427_18 | DOI Listing |
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