Hypertrophic lichen planus (HLP) is a chronic variant of lichen planus with an estimated risk of 0.4% developing squamous cell carcinoma (SCC) in later years. We report the case of a 12-year- old boy with history of hypertrophic lichen planus since 4 years of age, with malignant transformation into squamous cell carcinoma along with lymph node metastasis.
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http://dx.doi.org/10.4103/idoj.IDOJ_27_19 | DOI Listing |
J Pers Med
November 2024
Otolaryngology Unit, Santi Paolo e Carlo Hospital, Department of Health Sciences, Università degli Studi di Milano, 20142 Milan, Italy.
Chronic graft-versus-host disease (cGVHD) and oral lichen planus (LPO) are chronic inflammatory conditions with similar oral manifestations. This study aimed to assess whether serum and salivary cytokines (IL-1α, IL-6, IL-17) could serve as reliable biomarkers for cGVHD. A prospective cohort study was conducted involving cGVHD patients, LPO patients, and healthy controls.
View Article and Find Full Text PDFDent J (Basel)
December 2024
Department of Dermatology, National Medical Institute of the Ministry of the Interior and Administration, 02-507 Warsaw, Poland.
Our study aimed to establish the basic reliability parameters of direct immunofluorescence test results in patients with oral lichen planus. We conducted an evaluation of individual antibody classes in the DIF and ELISA (BP180 antigen), comparing these results with the classical histopathological (HP) examination in a group of patients treated within the standard healthcare in our clinic. Among 66 participants with oral changes indicative of LP, only 50% received histopathological confirmation of the LP diagnosis.
View Article and Find Full Text PDFFront Immunol
December 2024
Department of Thoracic Surgery, Affiliated Hospital of Southwest Medical University, Luzhou, China.
Background: Lichen planus (LP), an autoimmune disorder, remains incompletely understood in terms of its etiological mechanisms. This study aims to elucidate causal relationships among immune cell populations, plasma metabolites, and lichen planus using Mendelian randomization (MR) techniques.
Methods: Employing a two-sample, two-step MR approach, with single nucleotide polymorphisms (SNP) serving as genetic instruments for both exposures and mediators, this study minimizes biases from confounding and reverse causality.
BDJ Open
December 2024
Medical Biochemistry and Molecular Biology, Faculty of Medicine, Cairo University, Cairo, Egypt.
Background: Oral Lichen Planus is one of the most popular chronic mucocutaneous diseases. It is classified as potentially malignant lesions. Many microRNAs can be used as biological markers for the disease and for its malignant transformation.
View Article and Find Full Text PDFWiad Lek
December 2024
PROVINCIAL HOSPITAL NAMED AFTER SAINT LUKE, TARNOW, POLAND.
Injectable platelet-rich fibrin (i-PRF) is a novel platelet concentrate that has been employed in dentistry with the objective of promoting tissue regeneration and healing. In contrast to platelet-rich plasma (PRP), i-PRF is more straightforward to handle, more cost-effective, and free from anticoagulants, which reduces biochemical alterations. The i-PRF procedure was developed in 2014 by adjusting the centrifugation forces.
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