AI Article Synopsis
- Histamine intolerance (HIT) is linked to excess histamine in the body and may be managed with the enzyme diamine oxidase (DAO) for digestion.
- During a 4-week study, 28 patients took DAO capsules before meals, leading to significant improvement in HIT-related symptoms.
- After stopping DAO, symptoms worsened again, indicating that DAO supplementation effectively reduces both the number and intensity of symptoms associated with HIT.
Article Abstract
Histamine intolerance (HIT) is thought to be caused by a disproportionate amount of histamine in the body. The enzyme diamine oxidase (DAO) is considered for the gastrointestinal degradation of histamine. For this open-label interventional pilot study, we identified 28 patients with HIT. For 4 weeks, they were instructed to take DAO capsules before meals. Then, throughout a follow-up period, they were instructed not to take the DAO. We used a questionnaire that included 22 symptoms, which were divided into 4 categories, as well as a symptom severity score. All symptoms improved significantly during the oral supplementation of DAO. During the follow-up period, without DAO supplementation, the symptoms sum scores increased again. The symptom intensity score was reduced for all symptoms. We have demonstrated, a significant reduction of every HIT-related symptom and its intensity due to DAO oral supplements. The ClinicalTrials.gov identifier (NCT number) is NCT03298568.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859183 | PMC |
| http://dx.doi.org/10.1007/s10068-019-00627-3 | DOI Listing |
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