Synthesis and spectroscopic characterization of novel methoxy bridged benzimidazolyl-substituted phthalocyanines as potent inhibitors of urease.

Spectrochim Acta A Mol Biomol Spectrosc

Department of Chemistry, Faculty of Arts and Sciences, Giresun University, 28049 Giresun, Turkey.

Published: March 2020

In this study, novel peripherally 4-[(1H-benzimidazol-1-yl)methoxy] substituted Zn(II) (3) Cu(II) (4) and Co(II) (5) phthalocyanines were prepared and their structures were characterized spectroscopically. The light absorption behaviors of the synthesized compounds (3-5) were studied by UV-Vis spectroscopy at different concentrations in different solvents. The urease inhibition activities of the synthesized compounds were also investigated. Among the synthesized molecules, compound 4 showed the best inhibitory effect against jack bean urease with IC values of 0.0036 ± 0.0010 μM.

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http://dx.doi.org/10.1016/j.saa.2019.117804DOI Listing

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