A phytochemical investigation on the 90% ethanol aqueous extract of the aerial part of led to the isolation of three new monoterpenoid indole alkaloids, kopsiarborines A-C (). The new structures were elucidated by using spectroscopic data (NMR, IR, UV, and MS). The isolated alkaloids were tested for cytotoxic potentials against six human lung cancer cell lines (A549, ATCC, H446, H460, H292, and 95-D). As a result, alkaloids and exhibited significant cytotoxic activities against all the tested tumor cell lines with IC values less than 20 µM.
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| http://dx.doi.org/10.1080/10286020.2019.1680646 | DOI Listing |
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