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Extraosseous manifestations are found in less than 5% of patients with multiple myeloma. They can arise in any tissue, and their presence has been associated with more aggressive disease. We present FDG PET/CT findings of immunoglobulin A κ multiple myeloma with innumerable hypermetabolic right lower extremity lesions of cutaneous and subcutaneous involvement of plasmablastic plasma cell myeloma in a 44-year-old man.
View Article and Find Full Text PDFAn Update on EBV-related Cutaneous Lymphoproliferative Disorders: a Systematic Review.
Actas Dermosifiliogr
November 2024
Universidad de Zaragoza, Zaragoza, España; Servicio de Anatomía Patológica, Hospital Clínico Universitario Lozano Blesa, Zaragoza, España.
Epstein Barr virus (EBV) positive B lymphoproliferative disorders (LPD) with cutaneous involvement include a series of rare entities that go from indolent processes to aggressive lymphomas. B-cell EBV+ LPD mainly affect immunocompromised patients while T-cell EBV+ LPD are more prevalent in specific geographic regions such as Asia, Central America, and South America. Since the latest WHO-EORTC classification of cutaneous lymphomas in 2018, significant changes have been included in the new classifications of hematological malignancies.
View Article and Find Full Text PDFEpstein-Barr virus-positive, primary cutaneous marginal zone lymphoma, with transformation: Case report and review of the literature.
Am J Clin Pathol
September 2024
Department of Pathology, Division of Dermatology, Department of Hematology and Hematopoietic Cell Transplantation, and Beckman Research Institute, City of Hope Medical Center, Duarte, CA, US.
Article Synopsis
- Epstein-Barr Virus (EBV) positive primary cutaneous marginal zone lymphoma (PCMZL) is rare and can transform into more aggressive forms, like plasmablastic lymphoma (PBL), which is often fatal.
- The case discussed involves a patient with multifocal PCMZL who experienced a sequence of transformations, eventually leading to disease progression and death, despite various treatments, with genetic mutations similar across lymphomas indicating a common origin.
- A review of 18 cases shows that nearly half of patients with transformed PCMZL succumbed to the disease, particularly those diagnosed with multiple disease sites, highlighting the poor prognosis associated with this transformation.
Skin Involvement by Hematological Neoplasms with Blastic Morphology: Lymphoblastic Lymphoma, Blastoid Variant of Mantle Cell Lymphoma and Differential Diagnoses.
Cancers (Basel)
August 2023
Pathology Unit, Azienda Ospedaliera Santa Maria di Terni, University of Perugia, 05100 Terni, Italy.
Hematological neoplasms sharing a blastic morphology may involve the skin. The skin may be either the primary site of occurrence of hematological malignancies with blastic features or cutaneous lesions are the first manifestation of an underlying systemic malignancy. The assessment of skin biopsies of hematological neoplasms with blastic features poses diagnostic problems and requires expert hematopathologists considering a wide range of differential diagnoses.
View Article and Find Full Text PDF[A rapidly growing skin lesion on the sternum].
Ned Tijdschr Geneeskd
July 2023
Zaans medisch centrum, afd. Interne Geneeskunde, Zaandam.
This case involves a man with a medical history of multiple myeloma and osseous metastasis of prostate carcinoma. He presented with a progressively growing red tumor on his chest for the past three weeks. Histopathological examination revealed many atypical CD0138-positive plasmablastic cells, which matches a cutaneous manifestation of multiple myeloma.
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