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| http://dx.doi.org/10.1097/RHU.0000000000001279 | DOI Listing |
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The role of C-reactive protein and ferritin in the diagnosis of HLH, adult-onset still's disease, and COVID-19 cytokine storm.
Sci Rep
December 2024
International Collaboration On Repair Discoveries, School of Biomedical Engineering, University of British Columbia, Vancouver, BC, Canada.
Cytokine storm syndromes such as hemophagocytic lymphohistiocytosis (HLH), Adult-onset Still's disease (AOSD), and COVID-19 cytokine storm (CCS) are characterized by markedly elevated inflammatory cytokines. However clinical measurement of serum cytokines is not widely available. This study examined the clinical utility of C-reactive protein (CRP) and ferritin, two inexpensive and widely available inflammatory markers, for distinguishing HLH from AOSD and CCS.
View Article and Find Full Text PDFHaemophagocytic Lymphohistiocytosis Triggered by Cytomegalovirus Reactivation in An Immunosuppressed Patient with Pauci-Immune Glomerulonephritis.
Eur J Case Rep Intern Med
November 2024
CHU Marie-Curie Humani, Charleroi, Belgium.
Unlabelled: We report on a 67-year-old male patient admitted to the Internal Medicine department for fever, joint pain and exertional dyspnoea. Two months before his admission, the patient had been diagnosed with pauci-immune necrotising glomerulonephritis, for which he had been treated with rituximab and corticosteroids. Upon admission the patient was stable, but within a few hours he became unstable as liver failure and acute cytopaenia occurred.
View Article and Find Full Text PDFClassification and Regression Tree Analysis in Adult Hemophagocytic Syndrome: Identifying Acute Heart Failure Predictors in ICU Patients.
J Inflamm Res
November 2024
Ege University, Faculty of Medicine, Department of Internal Medicine, Division of Intensive Care, Izmir, Turkey.
Article Synopsis
- Hemophagocytic syndrome (HPS) is a serious condition that can lead to heart failure, and this study aimed to find out which factors are predictors of developing heart failure in these patients.* -
- Using CART analysis on 146 HPS patients, researchers discovered that factors like cardiothoracic ratio (CTR), NT-proBNP levels, and C-reactive protein (CRP) are significant predictors, with CTR being the most critical one.* -
- The results underscore the importance of early identification of these predictors to improve patient outcomes and inform future research on managing heart failure in HPS.*
Regorafenib-Triggered Hemophagocytic Lymphohistiocytosis: A Report of Two Cases.
Cureus
October 2024
Department of Medical Oncology, Oncopole Claudius Regaud, Toulouse, FRA.
Hemophagocytic lymphohistiocytosis (HLH) is a rare, potentially fatal condition, characterized by overactivation of the immune system. It can manifest as primary or secondary when triggered by infections, neoplasms, or medications. We report here two cases of regorafenib-induced HLH, one of which was life-threatening.
View Article and Find Full Text PDFEpstein-Barr Virus encephalitis associated hemophagocytic lymphohistiocytosis in childhood-onset systemic lupus erythematosus: a case-based review.
Pediatr Rheumatol Online J
October 2024
Division of Rheumatology, Department of Pediatrics, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Bangkok, 10300, Thailand.
Article Synopsis
- Hemophagocytic lymphohistiocytosis (HLH) is an immune disorder causing severe inflammation, categorized into primary (familial) and secondary (acquired) types; secondary HLH can occur due to various triggers, including infections like Epstein-Barr virus (EBV).
- A 12-year-old girl with childhood-onset systemic lupus erythematosus (SLE) developed fever, seizures, and altered mental status, raising concerns for neuropsychiatric SLE or infections, leading to extensive testing and treatment.
- Diagnosis of HLH was confirmed through blood tests showing abnormal cell counts and bone marrow analysis revealing hemophagocytic activity, along with CSF analysis that identified EBV as the
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