The purpose is to analyze literature data on currently used and promising approaches to the treatment of food allergies in children. It reviewed the variants of allergen-specific food allergy therapy (AST-FA), which allow expanding the range of consumed products to which no reaction is manifested, reducing the risk of developing potential life-threatening allergic reactions if they are accidentally ingested. AST-FA is currently the only potentially effective method of IgE-mediated FA. One of the new options for pathogenetically substantiated therapy of FA is the use of biological drugs that increase the ability to achieve immune tolerance to food antigens. It seems reasonable to consider the possibilities of using a number of non-allergen-specific molecules - cytokines, Toll-like receptors, various cell populations, probiotics and gene therapy - as potential targets for treating patients with multiple food allergies. Further studies are needed to determine the optimal dose, duration of treatment, and long-term effects of biologics used in the treatment of FA.
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J Investig Allergol Clin Immunol
January 2025
Hospital La Paz Institute for Health Research (IdiPAZ), Madrid, Spain.
Rev Med Suisse
January 2025
Service d'immunologie et d'allergologie, Hôpitaux universitaires de Genève, 1211 Genève 14.
In recent years, studies have focused on the in vitro diagnosis of immediate drug reactions, with new recommendations concerning the use of the basophil activation test. Air pollution, particularly fine particles with a diameter of less than or equal to 2.5 m (PM2.
View Article and Find Full Text PDFPrz Gastroenterol
May 2024
Department of Allergology, Clinical Immunology, and Internal Diseases, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Jan Biziel University Hospital No. 2 in Bydgoszcz, Poland.
Eosinophilic esophagitis (EoE) is a chronic immune-mediated esophageal disease, clinically characterised by symptoms of esophageal dysfunction and histologically by eosinophilic infiltration of its wall. The last 3 decades have seen a sharp increase in its incidence to the point that it is called the second most common esophageal disease after reflux disease in some recent studies. The main indicators of EoE are food allergens and in recent years the extremely important role of oral immunotherapy (OIT) in the development of this disease has also been increasingly raised.
View Article and Find Full Text PDFWorld Allergy Organ J
January 2025
Department of Pediatric Allergy and Immunology, Ankara Yıldırım Beyazıt University, Ankara, Turkey.
Background: The incidence of anaphylaxis is increasing worldwide. However, there is a lack of data on anaphylaxis trends in Türkiye. This study aims to analyse trends in anaphylaxis-related emergency department (ED) visits and examines factors associated with fatal anaphylaxis in Türkiye.
View Article and Find Full Text PDFPLoS One
January 2025
Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
End-user feedback early in product development is important for optimizing multipurpose prevention technologies for HIV and pregnancy prevention. We evaluated the acceptability of the 90-day dapivirine levonorgestrel ring (DPV-LNG ring) used for 14 days compared to a dapivirine-only ring (DVR-200mg) in MTN-030/IPM 041 (n = 23), and when used for 90 days cyclically or continuously in MTN-044/IPM 053/CCN019 (n = 25). We enrolled healthy, non-pregnant, HIV-negative women aged 18-45 in Pittsburgh, PA and Birmingham, AL (MTN-030 only).
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