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The study explored the effect of salidroside(SAL) on high fat-induced apoptosis in H9 c2 cardiomyocytes based on AMPK/mTOR/p70 S6 K pathway.H9 c2 cardiomyocytes were cultured in vitro and the lipotoxicity model of H9 c2 cardiomyocytes was constructed by 0.2 mmol·L~(-1) palmitic acid(PA) treatment for 24 hours.
View Article and Find Full Text PDFSera from women with different metabolic and menopause states differentially regulate cell viability and Akt activation in a breast cancer in-vitro model.
PLoS One
April 2022
Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas (IIBO), Universidad Nacional Autónoma de México (UNAM), Mexico City, Mexico.
Obesity is associated with an increased incidence and aggressiveness of breast cancer and is estimated to increment the development of this tumor by 50 to 86%. These associations are driven, in part, by changes in the serum molecules. Epidemiological studies have reported that Metformin reduces the incidence of obesity-associated cancer, probably by regulating the metabolic state.
View Article and Find Full Text PDFTAKTIC: A prospective, multicentre, uncontrolled, phase IB/II study of LY2780301, a p70S6K/AKT inhibitor, in combination with weekly paclitaxel in HER2-negative advanced breast cancer patients.
Eur J Cancer
December 2021
Department of Medical Oncology, Institut Paoli-Calmettes, Marseille, France; Predictive Oncology Laboratory, CRCM, Inserm U1068, CNRS UMR7258, Institut Paoli-Calmettes, Aix-Marseille Univ, Marseille, France. Electronic address:
Background: Hormone-resistant HER2-negative or triple-negative advanced breast cancers (ABC) are routinely treated with paclitaxel chemotherapy. LY2780301 is a dual inhibitor of p70 ribosomal protein S6 kinase and AKT. The TAKTIC study aimed at exploring the combination of paclitaxel and LY2780301 in this population.
View Article and Find Full Text PDFGluN2A-ERK-mTOR pathway confers a vulnerability to LPS-induced depressive-like behaviour.
Behav Brain Res
January 2022
Department of Molecular Biology and Endocrinology, "VINČA" Institute of Nuclear Sciences - National Institute of thе Republic of Serbia, University of Belgrade, Belgrade. Electronic address:
Inflammation plays a key role in the pathogenesis of the major depressive disorder. Namely, neuroinflammation can induce the production of neuroactive metabolites that interfere with N-methyl-D-aspartate receptors (NMDAR)-mediated glutamatergic neurotransmission and contribute to depressive-like behaviour. On the other hand, mammalian target of rapamycin (mTOR) activity with synaptogenic effects is the main mediator of antidepressant effects of several potent NMDAR antagonists.
View Article and Find Full Text PDFEgg White Protein Promotes Developmental Growth in Rodent Muscle Independently of Leucine Content.
J Nutr
January 2022
Faculty of Sports and Health Science, Fukuoka University, Fukuoka, Japan.
Background: Leucine has unique anabolic properties, serving as a nutrient signal that stimulates muscle protein synthesis.
Objective: We tested whether the leucine concentration is the only factor determining protein quality for muscle development.
Methods: We selected 3 dietary proteins: casein (CAS), egg white protein (EWP), and albumin (ALB), representing the leucine concentrations of ∼8.
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