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Gramicidin S-inspired antimicrobial cyclodextrin to disrupt gram-negative and gram-positive bacterial membranes. | LitMetric

Gramicidin S-inspired antimicrobial cyclodextrin to disrupt gram-negative and gram-positive bacterial membranes.

Medchemcomm

Materials Science and Engineering , Graduate School of Engineering , Nagoya Institute of Technology, Gokiso-cho, Showa-ku , Nagoya 466-8555 , Japan . Email:

Published: August 2019

A membrane-active antimicrobial peptide gramicidin S-like amphiphilic structure was prepared from cyclodextrin. The mimic was a cyclic oligomer composed of 6-amino-modified glucose 2,3-di--propanoates and it exhibited antimicrobial activity against Gram-positive and Gram-negative bacteria, together with no resistance development and low haemolytic activity against red blood cells.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6836745PMC
http://dx.doi.org/10.1039/c9md00229dDOI Listing

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