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http://dx.doi.org/10.1183/20734735.0218-2019 | DOI Listing |
mSystems
January 2025
Zoological Institute, Kiel University, Kiel, Germany.
The microbiomes of host organisms and their direct source environments are closely linked and key for shaping microbial community dynamics. The relationship between these linked dynamics is largely unexplored because source substrates are usually unavailable. To address this current knowledge gap, we employed bacteriovorous nematodes as a unique model system, for which source substrates like rotting apples can be easily collected.
View Article and Find Full Text PDFACS Sens
January 2025
Materials Interfaces Center, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, P. R. China.
Over recent years, the LUMinescent AntiBody Sensor (LUMABS) system, utilizing bioluminescence resonance energy transfer (BRET), has emerged as a highly effective method for antibody detection. This system incorporates NanoLuc (Nluc) as the donor and fluorescent protein (FP) as the acceptor. However, the limited Stokes shift of FP poses a challenge, as it leads to significant spectral cross-talk between the excitation and emission spectra.
View Article and Find Full Text PDFNanomaterials (Basel)
December 2024
School of Mathematics and Physics, Jiangsu University of Technology, Changzhou 213100, China.
This review highlights recent progress in utilizing iron oxide nanoparticles (IONPs) as a safer alternative to gadolinium-based contrast agents (GBCAs) for magnetic resonance imaging (MRI). It consolidates findings from multiple studies, discussing current T contrast agents (CAs), the synthesis techniques for IONPs, the theoretical principles for designing IONP-based MRI CAs, and the key factors that impact their T contrast efficacy, such as nanoparticle size, morphology, surface modifications, valence states, and oxygen vacancies. Furthermore, we summarize current strategies to achieve IONP-based responsive CAs, including self-assembly/disassembly and distance adjustment.
View Article and Find Full Text PDFSmall
January 2025
Department of Chemistry, McGill University, 801, Sherbrooke St. West, Montreal, QC, H3A 0B8, Canada.
Oligonucleotide therapeutics, including antisense oligonucleotides and small interfering RNA, offer promising avenues for modulating the expression of disease-associated proteins. However, challenges such as nuclease degradation, poor cellular uptake, and unspecific targeting hinder their application. To overcome these obstacles, spherical nucleic acids have emerged as versatile tools for nucleic acid delivery in biomedical applications.
View Article and Find Full Text PDFBMC Plant Biol
January 2025
Beijing Life Science Academy, Beijing, 102200, China.
Background: Fungal communities around plant roots play crucial roles in maintaining plant health. Nonetheless, the responses of fungal communities to bacterial wilt disease remain poorly understood. Here, the structure and function of fungal communities across four consecutive compartments (bulk soil, rhizosphere, rhizoplane and root endosphere) were investigated under the influence of bacterial wilt disease.
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