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| http://dx.doi.org/10.1136/bcr-2019-233034 | DOI Listing |
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Predicting intra-abdominal candidiasis in elderly septic patients using machine learning based on lymphocyte subtyping: a prospective cohort study.
Front Pharmacol
December 2024
Department of Critical Care Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
Objective: Intra-abdominal candidiasis (IAC) is difficult to predict in elderly septic patients with intra-abdominal infection (IAI). This study aimed to develop and validate a nomogram based on lymphocyte subtyping and clinical factors for the early and rapid prediction of IAC in elderly septic patients.
Methods: A prospective cohort study of 284 consecutive elderly patients diagnosed with sepsis and IAI was performed.
In post-liver transplant patients, esophagitis presents a diagnostic and management challenge due to the potential for opportunistic infections. This case describes a 59-year-old female with primary sclerosing cholangitis who underwent orthotopic liver transplantation six years prior. She presented with dysphagia, and her medical history included immunosuppression with prednisone, tacrolimus, and mycophenolate and a history of achalasia treated with esophageal peroral endoscopic myotomy.
View Article and Find Full Text PDFEnhancing ascitic fungal infection diagnosis through next-generation sequencing: a pilot study in surgical ICU patients.
Front Cell Infect Microbiol
November 2024
Institute of Medical Microbiology and Hygiene, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.
Objectives: Ascites, often associated with critical pathologies such as liver cirrhosis or bowel perforation, can be complicated by fungal infection, increasing mortality especially in intensive care settings and demanding rapid diagnosis and adequate treatment. Traditional microbiological diagnostic methods have limited sensitivity in accurately identifying fungal pathogens in ascitic fluid. Alternative diagnostic methods may offer important insights to enable guiding of antifungal therapy and refining empirical treatment strategies.
View Article and Find Full Text PDFDouble Trouble: The Perilous Intersection of Amoebic Colitis and Candida Infection Leading to Colonic Perforation.
Cureus
October 2024
Department of Surgical Gastroenterology, Sree Balaji Medical College and Hospital, Chennai, IND.
Amoebic colitis, a parasitic infection caused by , can lead to severe gastrointestinal symptoms. The clinical manifestations can vary widely, from being an asymptomatic carrier to experiencing severe colitis and even colonic perforation. Surgical treatment for fulminant amoebic colitis and colonic perforation should be carried out at the earliest.
View Article and Find Full Text PDFClinical Outcomes of Infectious Keratitis Associated with Contact Lens Wear Following Penetrating Keratoplasty: A Case Series.
Int Ophthalmol
November 2024
Department of Ophthalmology and Visual Neurosciences, University of Minnesota, 516 Delaware St SE, Minneapolis, MN, 55455, USA.
Purpose: To report on the clinical characteristics, and outcomes of patients who developed infectious keratitis associated with contact lens (CL) wear following penetrating keratoplasty (PK).
Methods: A retrospective chart review was performed to identify all patients who underwent PK between November 2012 and January 2023 at a single tertiary referral practice, and subsequently developed CL related infectious keratitis. 74 patients using CL following PK were identified.
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