AI Article Synopsis
- A new and easy method for creating C-ring substituted luotonins and vasicinones has been developed using a special acid to facilitate a specific chemical reaction called aza-Nazarov cyclization.
- This reaction involves compounds known as quinazolinonyl enones and is influenced by the presence of protons in the reaction environment.
- The way the cyclization occurs, meaning which parts of the molecules are affected, relies heavily on how many protons are available during the process.
Article Abstract
A facile synthesis of C-ring substituted luotonins and vasicinones has been realized via a super-acid-mediated aza-Nazarov cyclization of quinazolinonyl enones. The regioselectivity of the cyclization is highly dependent on proton availability in the reaction medium.
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| http://dx.doi.org/10.1021/acs.orglett.9b03586 | DOI Listing |
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