AI Article Synopsis
- - Six new secocycloartane glycosides were extracted from the flowers of Lam. using a method that combines biological activity assessment with fractionation.
- - The structures of these compounds were confirmed using nuclear magnetic resonance (NMR), mass spectrometry (MS), and X-ray crystallography, marking them as the first examples of a specific type of glycosides.
- - These compounds demonstrated notable anti-activity in tests, showed weak toxicity against RAW 264.7 cells, and were further evaluated for their effects against leishmaniasis and malaria parasites.
Article Abstract
Six new secocycloartane glycosides (-) were isolated from the ethanol extract of the flowers of Lam. on the basis of bioassay-guided fractionation. Their structures were determined by the application of NMR and MS data analyses together with X-ray crystallographic analyses for compounds and . Compounds - represent the first examples of 9,10-seco-29-norcycloartane glycosides. These compounds showed significant in vitro anti- activity, and no activity against either or . Significant activity was observed for and against . All compounds displayed weak cytotoxicity against RAW 264.7 cells. The in vitro antileishmanial and antiplasmodial activities of - were also evaluated.
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| http://dx.doi.org/10.1021/acs.jnatprod.9b00149 | DOI Listing |
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