Modular polyketide synthases (PKSs) are enzymatic assembly lines that fuse carbon fragments into complex chiral products. Here, their synthetic logic is employed to chemoenzymatically generate two-stereocenter triketides. Each of the four stereoisomers was constructed in a stereocontrolled manner using C-acylation and two PKS ketoreductases possessing opposite stereoselectivities.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7172026 | PMC |
| http://dx.doi.org/10.1039/c9cc07966a | DOI Listing |
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General chemoenzymatic route to two-stereocenter triketides employing assembly line ketoreductases.
Chem Commun (Camb)
December 2019
Department of Chemistry, The University of Texas at Austin, 100 E. 24th St., Austin, TX 78712, USA.
Modular polyketide synthases (PKSs) are enzymatic assembly lines that fuse carbon fragments into complex chiral products. Here, their synthetic logic is employed to chemoenzymatically generate two-stereocenter triketides. Each of the four stereoisomers was constructed in a stereocontrolled manner using C-acylation and two PKS ketoreductases possessing opposite stereoselectivities.
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