All movements are generated by the activation of motoneurons, and hence their input-output properties define the final step in processing of all motor commands. A major challenge to understanding this transformation has been the striking nonlinear behavior of motoneurons conferred by the activation of persistent inward currents (PICs) mediated by their voltage-gated Na and Ca channels. In this review, we focus on the contribution that these PICs make to motoneuronal discharge and how the nonlinearities they engender impede the construction of a comprehensive model of motor control.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132324 | PMC |
| http://dx.doi.org/10.1152/physiol.00026.2019 | DOI Listing |
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