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| http://dx.doi.org/10.1159/000500642 | DOI Listing |
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Negative pressure breathing: the response of human respiration and circulation to different levels of rarefaction during inspiration.
Front Physiol
November 2024
Department of Cardiovascular and Respiratory Physiology in Extreme Environments, Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Russia.
Article Synopsis
- - Negative pressure breathing (NPBin) is a technique that lowers pressure in the respiratory tract during inhalation, aiming to boost blood flow to the heart and counteract fluid shifts in space.
- - This study analyzed the effects of NPBin for 25 minutes at pressure reductions of -10 to -25 cmHO, using various non-invasive measurement techniques to assess changes in circulation and respiration in healthy volunteers.
- - Results showed that NPBin increased tidal volume and decreased respiratory rate without significantly affecting overall minute ventilation, while circulatory parameters showed increased amplitude during breathing cycles, indicating a complex interaction between respiration and circulation.
Comorbidities in early-onset sporadic versus presenilin-1 mutation-associated Alzheimer disease dementia: Evidence for dependency on Alzheimer disease neuropathological changes.
J Neuropathol Exp Neurol
December 2024
Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, AZ, United States.
Article Synopsis
Construction of an animal model of autism based on interaction between cerebellar histological, immunohistochemical, and biochemical changes in adult male albino rat.
Ultrastruct Pathol
January 2025
Department of Medical Histology and Cell Biology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Methods: Twelve pregnant female rats were divided into a control group and a valproic acid (VPA) treated group (injected intraperitoneally on embryonic day 12 with 600 mg/kg body weight of VPA). Neurobehavioral tests were conducted on the offspring of both groups. The cerebellum was studied by light and electron microscopy as well as GFAP and caspase-3 immunohistochemical staining.
View Article and Find Full Text PDF'Like nets or cobwebs': Kenelm Digby, Isaac Newton and the problem of rarefaction.
Br J Hist Sci
October 2024
Science Studies Unit, University of Edinburgh, UK.
This article aims to bring out the problematic nature of condensation and rarefaction for early modern natural philosophers by considering two historically significant attempts to deal with it, first by Sir Kenelm Digby in his (1644), and subsequently by Isaac Newton, chiefly in manuscript works associated with the (1687). It is argued that Digby tried to sidestep the problem of variation in density and rarity by making it a fundamental starting point for his physics. But he also brought out the difficulties of dealing with condensation and rarefaction within the mechanical philosophy, whether that philosophy was plenist or allowed for void space.
View Article and Find Full Text PDFPulmonary Hypertension and Right Ventricle: A Pathophysiological Insight.
Clin Med Insights Cardiol
September 2024
Trauma and Surgery Research Center, AJA University of Medical Sciences, Tehran, Iran.
Background: Pulmonary hypertension (PH) is a pulmonary vascular disease characterized by elevated pulmonary vascular pressure. Long-term PH, irrespective of its etiology, leads to increased right ventricular (RV) pressure, RV hypertrophy, and ultimately, RV failure.
Main Body: Research indicates that RV failure secondary to hypertrophy remains the primary cause of mortality in pulmonary arterial hypertension (PAH).
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