In June of 2019, a working group convened by the International Agency for Research on Cancer [IARC] concluded that "night shift work" is probably carcinogenic to humans (a Group 2A carcinogen). This was based on sufficient evidence of cancer and strong mechanistic evidence in experimental animals and limited evidence from human epidemiological studies. The biological basis from experimental work is clear and compelling: Disturbed chronobiology such as due to alterations in the light-dark schedule which shift-workers experience is associated with carcinogenicity. But is it correct to assume in epidemiological studies that "night shift work" provides the same dose of disturbed chronobiology to all night workers and that disturbed chronobiology from activities outside of work does not count? Both chronobiological theory and supporting evidence suggest that much-needed future epidemiology should address these questions and should consider disturbed chronobiology in all walks of life.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882045 | PMC |
| http://dx.doi.org/10.1186/s12995-019-0249-6 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Chronobiology in Paediatric Neurological and Neuropsychiatric Disorders: Harmonizing Care with Biological Clocks.
J Clin Med
December 2024
Scientific Institute IRCCS "E. Medea", Scientific Direction, 23842 Bosisio Parini, Italy.
: Chronobiology has gained attention in the context of paediatric neurological and neuropsychiatric disorders, including migraine, epilepsy, autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), and post-traumatic stress disorder (PTSD). Disruptions in circadian rhythms are associated with key symptoms such as sleep disturbances, mood dysregulation, and cognitive impairments, suggesting a potential for chronobiology-based therapeutic approaches. : This narrative review employs a systematic approach to identify relevant studies through searches of three major scientific databases, NCBI/PubMed, ScienceDirect, and Scopus, up to July 2024.
View Article and Find Full Text PDFMelatonin Alleviates Circadian Rhythm Disruption-Induced Enhanced Luteinizing Hormone Pulse Frequency and Ovarian Dysfunction.
J Pineal Res
January 2025
Department of Obstetrics and Gynecology, West China Second University Hospital of Sichuan University, Chengdu, Sichuan, China.
Circadian rhythm disruption (CRD), stemming from sleep disorders and/or shift work, is a risk factor for reproductive dysfunction. CRD has been reported to disturb nocturnal melatonin signaling, which plays a crucial role in female reproduction as a circadian regulator and an antioxidant. The hypothalamic-pituitary-ovarian (HPO) axis regulates female reproduction, with luteinizing hormone (LH) pulse pattern playing a pivotal role in folliculogenesis and steroidogenesis.
View Article and Find Full Text PDFCircadian Disruption in Glaucoma: Causes, Consequences, and Countermeasures.
Front Biosci (Landmark Ed)
December 2024
Halberg Chronobiology Center, University of Minnesota, Minneapolis, MN 55455, USA.
This review explores the intricate relationship between glaucoma and circadian rhythm disturbances. As a principal organ for photic signal reception and transduction, the eye plays a pivotal role in coordinating the body's circadian rhythms through specialized retinal ganglion cells (RGCs), particularly intrinsically photosensitive RGCs (ipRGCs). These cells are critical in transmitting light signals to the suprachiasmatic nucleus (SCN), the central circadian clock that synchronizes physiological processes to the 24-hour light-dark cycle.
View Article and Find Full Text PDFHigh sleep reactivity in shift workers is associated with increased sleep disturbance, mood problems, and reduced quality of life.
Sleep Med
December 2024
Department of Psychiatry and Center for Sleep and Chronobiology, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Republic of Korea. Electronic address:
Introduction: Shift work disrupts circadian rhythms, causing sleep and mood problems. Sleep reactivity-the sensitivity of sleep to stress-may affect how shift workers cope with these disruptions. This study investigated the relationship between sleep reactivity and shift work, exploring associations between sleep reactivity and sleep disturbance, mood symptoms, and quality of life in shift workers.
View Article and Find Full Text PDFCircuit mechanism underlying fragmented sleep and memory deficits in 16p11.2 deletion mouse model of autism.
iScience
December 2024
Department of Neuroscience, Chronobiology and Sleep Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Article Synopsis
- Sleep disturbances are common in children with autism spectrum disorder (ASD) and are linked to the severity of their symptoms, especially memory issues.* -
- In a study using a mouse model of ASD, researchers found that non-rapid eye movement sleep (NREMs) was fragmented, which correlated with increased activity in certain brain neurons during sleep.* -
- By inhibiting these neurons, the study showed that sleep could be stabilized and memory improved, highlighting the significant role of the locus coeruleus noradrenergic system in regulating both sleep and memory in ASD.*
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!