AI Article Synopsis
- Hypericaceae is a genus known for its therapeutic properties, especially in wound healing.
- Previous research on Brazilian species indicated their ability to promote keratinocyte proliferation.
- The current study found that specific phloroglucinol derivatives, particularly cariphenone B and uliginosin B, significantly enhanced cell proliferation in human keratinocytes, fibroblasts, and stem cells, confirming their potential as wound healing agents.
Article Abstract
The genus (Hypericaceae) is a recognized source of therapeutic agents, being some species widely used due to their wound healing properties. In a previous study, south Brazilian species and demonstrated potential to induce proliferation of keratinocytes. In the present study, the effect of phloroglucinol derivatives isolated from on cell proliferation of human keratinocytes, fibroblasts and stem cells was investigated. The best results, determined by the MTT assay, were achieved with cariphenone B at concentrations of 0.01 and 0.1 µM (122.3% and 114%, respectively) on HaCaT cells. Uliginosin B was able to induce the proliferation of mesenchymal stem cells (129% at 10 µM) and MRC5 fibroblasts (152.5% at 5 µM). These findings confirm the capacity of phloroglucinol derivatives to induce the cellular proliferation and reinforce the importance of species as potential sources of wound healing compounds.
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| http://dx.doi.org/10.1080/14786419.2019.1698576 | DOI Listing |
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