The majority of accepted papers in computational biology and biocomputing describe new software approaches to relevant biological problems. While journals and conferences often require the availability of software and source code, there are limited resources available to maximize the distribution and use of developed software within the scientific community. The accepted standard is to make source code available for new approaches in published work, the growing problem of system configuration issues, language, library version conflicts, and other implementation issues often impede the broad distribution, availability of software tools, and reproducibility of research. There are a variety of solutions to these implementation issues, but the learning curve for applying these solutions is steep. This tutorial demonstrates tools and approaches for packaging and distribution of published code, and provides methodological practices for the broad and open sharing of new biocomputing software.
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J Struct Biol
December 2024
Biocomputing Unit, Centro Nacional de Biotecnologia (CNB-CSIC), Darwin, 3, Campus Universidad Autonoma, 28049 Cantoblanco, Madrid, Spain. Electronic address:
Cryo-electron tomography is an imaging technique that allows the study of the three-dimensional structure of a wide range of biological samples, from entire cellular environments to purified specimens. This technique collects a series of images from different views of the specimen by tilting the sample stage in the microscope. Subsequently, this information is combined into a three-dimensional reconstruction.
View Article and Find Full Text PDFSci Rep
December 2024
Department of Biomedical Engineering, Michigan Technological University, 1400 Townsend Drive, Houghton, MI, USA.
Intracranial aneurysms (IA) pose significant health risks and are often challenging to manage. Computational fluid dynamics (CFD) simulation has emerged as a powerful tool for understanding lesion-specific hemodynamics in and around IAs, aiding in the clinical management of patients with an IA. However, the current workflow of CFD simulations is time-consuming, complex, and labor-intensive and, thus, does not fit the clinical environment.
View Article and Find Full Text PDFNucleic Acids Res
January 2025
National Health Commission Key Laboratory of Molecular Probes and Targeted Diagnosis and Therapy, Harbin Medical University, No.157 Baojian Road, Nangang District, Harbin 150081, China.
Structural variations (SVs) contribute to a large extent to genomic diversity and are highly relevant for various human genetic diseases. The sensitivity and specificity of SV identification have significantly improved with the development and widespread application of high-throughput sequencing, making clinical diagnosis and treatment more accurate. Therefore, the SV4GD (Structural Variation for Genetic Diseases, https://bio-computing.
View Article and Find Full Text PDFPLoS One
November 2024
School of Big Data and Computer Science Engineering, Chongqing College of Mobile Communication, Chongqing, Chongqing, China.
Nowadays, electronic computers use a "binary" numbering system, as opposed to "ternary" logic, which is closer to the way the human brain thinks. In this paper, the symmetric ternary system is applied to membrane computing for the first time. By combining the symmetric ternary system with membrane computing, this paper provides a more suitable arithmetic operation method for bio-computers, which breaks through the limitations of the traditional binary system in complex operations, and has a great potential for application in artificial intelligence and automatic learning in particular.
View Article and Find Full Text PDFMol Cell Proteomics
December 2024
Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark. Electronic address:
Mass spectrometry-based proteomics allows the quantification of thousands of proteins, protein variants, and their modifications, in many biological samples. These are derived from the measurement of peptide relative quantities, and it is not always possible to distinguish proteins with similar sequences due to the absence of protein-specific peptides. In such cases, peptide signals are reported in protein groups that can correspond to several genes.
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