AI Article Synopsis
- Resilience refers to the ability of systems, like ecosystems and bacterial communities, to return to their original state after experiencing a disturbance, highlighting its importance in ecology.
- While antibiotic resistance is a known issue in clinical settings, the concept of antibiotic resilience remains underexplored in bacteriology.
- The text suggests that if antibiotic resilience is to be better understood and measured, it could provide valuable insights into how bacteria recover from antibiotic treatments, with potential implications for clinical practice.
Article Abstract
Resilience is the capacity of systems to recover their initial state or functions after a disturbance. The concepts of resilience and resistance are complementary in ecology and both represent different aspects of the stability of ecosystems. However, antibiotic resilience is not used in clinical bacteriology whereas antibiotic resistance is a recognized major problem. To join the fields of ecology and clinical bacteriology, we first review the resilience concept from ecology, socio-ecological systems and microbiology where it is widely developed. We then review resilience-related concepts in microbiology, including bacterial tolerance and persistence, phenotypic heterogeneity and collective tolerance and resistance. We discuss how antibiotic resilience could be defined and argue that the use of this concept largely relies on its experimental measure and its clinical relevance. We review indicators in microbiology which could be used to reflect antibiotic resilience and used as valuable indicators to anticipate the capacity of bacteria to recover from antibiotic treatments.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6939251 | PMC |
| http://dx.doi.org/10.1098/rspb.2019.2408 | DOI Listing |
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